RESEARCH ON CHARACTERISTICS OF ANTIBIOTIC RESISTANCE AND RESULTS OF TREATMENT IN PATIENTS WITH VENTILATORASSOCIATED PNEUMONIA CAUSED BY MULTIDRUG-RESISTANT GRAM-NEGATIVE BACTERIA IN THE INTENSIVE CARE UNIT AT CAN THO CENTRAL GENERAL HOSPITAL IN 2019-20
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Abstract
Background: Ventilator-associated pneumonia is a severe condition with high mortality rate, mainly caused by multidrug-resistant Gram-negative bacteria. Objectives: Describing characteristics of antibiotics resistance, determining results of treatment and relating risk factors in patients with ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria in the intensive care unit at Can Tho Central General Hospital 2019-2020. Materials and methods: An analytical prospective cross-sectional descriptive study was conducted among 38 patients with ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria. Results: Acinetobacter baunannii isolates accounted for 78.9%. Extensively drug resistant (XDR) bacteria accounted for 71.1%. Although resistance to colistin was low, resistance to remaining antibiotics was more than 80%. Failure of treatment related statistically significantly to fever on the first day of pneumonia; increasing level of creatinin on the first and the third day of pneumonia. Conclusions: Extensively drug resistant Gram-negative bacteria, mostly Acinetobacter baunannii, have made it difficult in the choice of antibiotics for treatment due to high resistance. Administering colistin could help improve results of treatment.
Keywords
pneumonia, ventilator-associated, Gram-negative, multidrug-resistant
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