STUDY ON BOTANICAL CHARACTERISTICS AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF ARGEMONE MEXICANA L. - PAPAVERACEAE
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Abstract
Background: Pharmacological studies showed that some species of Argemone genus, Papaveraceae family contain many valuable biological activities such as antioxidant, inhibition of cancer cells, analgesic, anti-inflammatory, antibacterial, antifungal… The species Argemone mexicana L. was used in traditional medicine in many countries. The extract of this species possessed a number of pharmacological effects such as antibacterial, anti-inflammatory, inhibition of cancer cells, hypoglycemia, etc. Objectives: Investigating botanical characteristics and acetylcholinesterase inhibitory activity of A. mexicana L. Materials and methods: Powder of A. mexicana L. was characterized, microsurgical properties (stems and leaves) were evaluated by double dyeing method, acetylcholinesterase inhibitory activity was determined by Ellman's photometric method. Results: Characterized the microsurgery and powder of A. mexicana L., pointed out the most characteristic microbiological features to identify the studied species. Evaluation acetylcholinesterase inhibitory using total extract and fractionated extracts of A. mexicana L. with average activity of IC50 value ranged 25.29 to 86.66 µg/mL. The chloroform extract from the leaves of A. mexicana L. inhibited acetylcholinesterase with an IC50 value of 25.29 ± 0.22 µg/mL. Conclusion: The present study contributed to standardize the species A. mexicana L. in terms of microbiological characteristics and determined acetylcholinesterase inhibitory activity of the studied species.
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Keywords
Acetylcholinesterase, Argemone mexicana L., microsurgery, , powder characteristics
References
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