GIÁ TRỊ CỦA CYSTATIN C HUYẾT THANH TRONG ƯỚC ĐOÁN ĐỘ LỌC CẦU THẬN Ở BỆNH NHÂN TĂNG HUYẾT ÁP

Abstract

Background: Early detection of renal changes in hypertensive patients by assessing glomerular filtration rate with serum cystatin C is essential and has practical significance, has predictive value for morbidity and mortality in the future. Objectives: Investigated serum Cystatin C level and its clinical value in predicting the glomerular filtration rate (GFR) in hypertension patients. Materials and methods: A cross-sectional descriptive study with analysis on a control group consisting of 100 subjects with normal blood pressure and glomerular filtration rates and 304 hypertensive patients. Analysis of correlations, regression, calculation of area under the ROC curve for serum Cystatin C concentrations by SPSS. Results: The serum cystatin C in hypertensive patients was 1.7 ± 0.7mg/L higher than in the control group, 0.84 ± 0.09 mg/L (p<0.001). Cystatin C has high sensitivity, specificity, and ROC in predicting a decrease in GFR <60ml/min/1.73m² according to renal scintigraphy (93.94%; 87.5%; ROC 0.936; p<0.001). Increased levels of Cystatin C were an independent risk factor predicting a decrease in GFR <60 ml/min/1.73 m². The regression equation from ScysC to estimate mGFR=81.6 x ScysC^-0.892 has a diagnostic accuracy of 99%. Conclusions: The ScysC in hypertensive patients was 1.7 ± 0.7mg/L significantly higher than that in the non-hypertensive adult group, p<0.001. At the cut-off point ScysC=1.42mg/L, Scr=1.37mg/dL, ScysC all have better sensors and properties than Scr that allows mGFR mGFR <60mL/min/1.73m² to be detected.