KHẢO SÁT THÀNH PHẦN HÓA HỌC VÀ HOẠT TÍNH CHỐNG OXY HÓA CỦA LÁ VỐI (CLEISTOCALYX OPERCULATUS ROXB.), MYRTACEAE

Abstract

Background: In Viet Nam, leaves of Cleistocalyx operculatus Roxb. is a popular medicinal herb used for preparing traditional beverages or decoction. Extracts from these medicinal plants were demonstrated effectively in treatment of dyspepsia, diarrhea, abscess, chronic colitis, and dysentery. There are not many studies on the chemical compositions and the pharmacological activities of the leaves of this plant. Objectives: Preliminary analysis of phytochemical composition and survey antioxidant activity of the Cleistocalyx operculatus leaf extracts by the DPPH method. Materials and methods: The leaves of Cleistocalyx operculatus were analyzed phytochemical composition by the Ciulei method. Dried and ground to coarse powders, extracted with ethanol 70%, partitioned with increasing polar solvents (n- hexane, chloroform, ethyl acetate) to obtain extract and its fractions. The antioxidant activity was evaluated by DPPH scavenging assay. Results: The Cleistocalyx operculatus leaves contain flavonoids, polyphenols, essential oils, triterpenoids, polyuronics, phenolic acids, carotenoids. All of the extracts exhibited high antioxidant activity. Among them ethyl acetate fraction possessed higher levels of activity (82.05%). Conclusion: The leaf extracts of Cleistocalyx operculatus contain flavonoids, polyphenols, essential oils, triterpenoids, polyuronics, phenolic acids, carotenoids. All extracts, especially ethyl acetate extract, showed an antioxidant effect on the DPPH method.