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INVESTIGATION ON CHEMICAL CONSTITUENTS OF THE LICHEN USNEA UNDULATA AND PRELIMINARY APPLICATION IN SUNSCREEN CREAM
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Abstract
Background: Vietnam has a rich and diverse source of lichens, but it has not been properly researched in chemical constituents as well as biological activities. Lichens contain a variety of active ingredients as screening UV radiation. The search for natural sources of sunscreen active ingredients has become a concern of many scientists, especially in the context of the increasing intensity of UV radiation affecting the earth's surface. Objectives: Isolation and structure determination of compounds in the extracts. Preparation and evaluation of some criteria of sunscreen cream containing Usnea undulata extract. Materials and methods: U. undulata was collected in Lam Dong province, Vietnam. The extracts were prepared by using maceration with ultra sonic assistant. Using thin layer chromatography, column chromatography, and recrystallization to isolate compounds. The structure of isolated compound was elucidated by spectroscopic methods including MS, NMR, and in comparison with literature data. The cream is formulated by direct emulsification and rated SPF according to COLIPA guidelines. Results: Usnic acid was isolated from n-hexane extract. The sunscreen is formulated with a successful blend of lichen extracts as a source of UV protection active ingredients with SPF 25,2. The obtained sunscreen cream is smooth, white, and uniform. Conclusion: The study shows the potential of a product with UV radiation resistance from the lichen U. undulata collected in Lam Dong, Vietnam.
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Keywords
Lichen, sunscreen cream, Usnea undulata, UV
References
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