Article Sidebar
Views PDF: 426
INVESTIGATION ON CHEMICAL CONSTITUENTS OF THE LICHEN USNEA UNDULATA AND PRELIMINARY APPLICATION IN SUNSCREEN CREAM
Main Article Content
Abstract
Background: Vietnam has a rich and diverse source of lichens, but it has not been properly researched in chemical constituents as well as biological activities. Lichens contain a variety of active ingredients as screening UV radiation. The search for natural sources of sunscreen active ingredients has become a concern of many scientists, especially in the context of the increasing intensity of UV radiation affecting the earth's surface. Objectives: Isolation and structure determination of compounds in the extracts. Preparation and evaluation of some criteria of sunscreen cream containing Usnea undulata extract. Materials and methods: U. undulata was collected in Lam Dong province, Vietnam. The extracts were prepared by using maceration with ultra sonic assistant. Using thin layer chromatography, column chromatography, and recrystallization to isolate compounds. The structure of isolated compound was elucidated by spectroscopic methods including MS, NMR, and in comparison with literature data. The cream is formulated by direct emulsification and rated SPF according to COLIPA guidelines. Results: Usnic acid was isolated from n-hexane extract. The sunscreen is formulated with a successful blend of lichen extracts as a source of UV protection active ingredients with SPF 25,2. The obtained sunscreen cream is smooth, white, and uniform. Conclusion: The study shows the potential of a product with UV radiation resistance from the lichen U. undulata collected in Lam Dong, Vietnam.
Article Details
Keywords
Lichen, sunscreen cream, Usnea undulata, UV
References
2. Agnieszka G., Justyna P., Magdalena P. W., Elzbieta S. S., Pawel P. et al. (+)-Usnic Acid as a Promising Candidate for a Safe and Stable Topical Photoprotective Agent. Molecules. 2021. 26(17), 5224. doi: 10.3390/molecules26175224.
3. Peter V., Yngvar G., Knut A. S. Reprint of Efficient fungal UV-screening provides a remarkably high UV-B tolerance of photosystem II in lichen photobionts. Plant Physiology and Biochemistry. 2019. 134, 123-128. doi: 10.1016/j.plaphy.2018.09.030
4. Lana R., Viktoryia K. Herbal sun protection agents: Human studies. Clinics in Dermatology. 2018. 36(3), 369-375. doi: 10.1016/j.clindermatol.2018.03.014.
5. Branislav R., Marijana K. Lichens as a potential source of bioactive secondary metabolites. Lichen Secondary Metabolites: Bioactive Properties and Pharmaceutical Potential. 2015. 1-26. doi: 10.1007/978-3-319-13374-4_1.
6. Knut A. S., Yngvar G., Line N., Wolfgang B. UV‐induction of sun‐screening pigments in lichens. New Phytologist. 2003. 158(1), 91-100. doi: 10.1046/j.1469-8137.2003.00708.x
7. Andre A., Laurens B. Additions to the lichen flora of Vietnam, with an annotated checklist and bibliography. The Bryologist. 2006. 109(3), 358-371.
8. Trần Thị Hải Yến, Lê Thu Hường, Nguyễn Thị Thanh Duyên và cộng sự. Nghiên cứu bào chế và đánh giá chỉ số SPF của kem chống nắng chứa titan dioxid. Tạp chí khoa học: Khoa học Y Dược. 2019. 35(1), 54-60. doi: 10.25073/2588-1132/vnumps.4153.
9. Vaishali B., Manisha M. Evaluation Of In Vivo Sunscreen Activity Of Herbal Cream Containing Extract Of Curcuma Longa And Butea Monosperma. World Journal of Pharmaceutical research. 2014. 3 (2), 3026-3035.
10. Vaishali B., Neha W., Ashish T., Manisha M. Study Of Sunscreen Activity Of Herbal Cream Containing Flower Extract Of Nyctanthes Arbortristis L. And Tagetes Erecta L.. International Journal of Pharmaceutical Sciences Review and Research. 2011. 11(1), 142-146.
11. Rodrigo L. Antimycobacterial activity of Usnea steineri and its major constituent (+)-usnic acid. African J. Biotechnol. 2012. 11, 4636-9, doi: 10.5897/AJB11.3551.
12. Do Trung, Trang T. H. Nguyen, Thai N. Ha, Nguyen Van Lam, Nguyen T. T. Tram et al. Identification of Anti-Helicobacter pylori Compounds From Usnea undulata. Natural Product Communications. 2019. 14(7), 1934578X1986421. doi: 10.1177/1934578X19864212.