ĐẶC ĐIỂM MÔ BỆNH HỌC UNG THƯ VÚ CÓ BỘ BA DẤU ẤN HÓA MÔ MIỄN DỊCH ÂM TÍNH TẠI BỆNH VIỆN UNG BƯỚU ĐÀ NẴNG

Abstract

Background: Breast cancer is the most common cancer in women and is the leading cause of cancer death. According to the Globocan 2020 data, it is estimated that nearly 2.26 million new diagnoses, accounting for 11.7% of the total number of cancers. Objectives: To comment on the histological features of triple negative breast cancer by classification of the World Health Organization 2012. Materials and methods: We performed a cross-sectional descriptive study of 127 specimens on female breast carcinoma patients treated with mastectomy and negative triplet immunohistochemistry at Danang Oncology Hospital. Results: The mean age is 54.29±14.32 years old. The most common age group is 50-59, accounting for 26.8%. There are 6 histological types: Invasive carcinoma of no special type, metaplastic carcinoma, carcinoma with medullary features, invasive lobular carcinoma, mucinous carcinoma, and micropapillary carcinoma. In which, Invasive carcinoma of no special type is the histological type with the highest rate (90.6%), the three histological types with the lowest rate are micropapillary carcinoma, mucinous carcinoma and invasive lobular carcinoma (0.8%). Histological grade III accounted for the highest percentage (63.8%), none of which had histology grade I. There were 33% of cases with lymph node metastasis in which most of them were 1-3 lymph node metastasis (22.8%). High Ki67 index accounted for 91.3%; low Ki67 index accounted for 8.7%. Conclusion: The most common age group for triple negative breast cancer is 50-59. Invasive carcinoma of no special type is the histological type with the highest rate. Histological grade III is the most common. Most cases of triple negative breast cancer do not have lymph node metastasis. The high Ki67 index accounted for the highest percentage.