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RISK FACTORS, MICROBIOLOGY AND TREATMENT ASSESSMENTS OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH MECHANICAL VENTILATION AT THE INTENSIVE CARE UNIT – CAN THO CENTRAL GENERAL HOSPITAL FROM 2020 TO 2022
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Abstract
Background: Acute exacerbations of chronic obstructive pulmonary disease patients who needed mechanical ventilation have a mortality rate of 40%. 80% of these exacerbations was caused by infections, with at least 40%-50% bacterial infections. Objectives: Describe risk factors, microbiology and treatment assessments of AECOPD patients with mechanical ventilation. Materials and Methods: Prospective descriptive study of 41 Acute exacerbations of chronic obstructive pulmonary disease patients with mechanical ventilations at the intensive care unit, Can Tho Centreal General Hospital from 2020 to 2022. Results: 92.7% was male, with at least 20 pack-year smoking history. Mental changes in 65.9% and wheezes in 75.6%. Lab results were noted as follows: CRP 6.87 mg/dL, neutrophile 83.05%, blood pH at 7.25, PCO2 at 70.63 mmHg. General microbial cultures were positive in 43.9% of cases. In patients with respiratory infections, the positive rate was 44% A. baumanii was present in 40% of these samples, K. pneumoniae in 22%, P. aeruginosa in 22%, E. coli in 6%, Candida albicans in 6%. At the end of treatment, 70.7% of patients recovered and 29.3% died. Conclusions: Many risk factors can worsen the conditions of Acute exacerbations of chronic obstructive pulmonary disease patients, leading to the need of mechanical ventilation. General microbial cultures were postitive in 43.9% cases, most of them have hospital acquired origin.
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Keywords
Acute exacerbations of chronic obstructive pulmonary disease, mechanical ventilation, microbiology
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