VALUE OF SERUM CYSTATIN C IN PREDICTING ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE
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Abstract
Background: Acute kidney injury is a common complication in patients with acute decompensated heart failure and is associated with a poor prognosis. Objectives: To evaluate the value of serum cystatin C levels in predicting acute kidney injury in patients with acute decompensated heart failure. Materials and methods: A prospective cohort study was conducted on 106 patients with acute decompensated chronic heart failure admitted to the Department of Cardiology, Can Tho Central General Hospital from June 2024 to December 2025. Results: The incidence of acute kidney injury was 30.2%. Serum cystatin C levels were significantly higher in patients with acute kidney injury than in those without acute kidney injury (p < 0.05). Elevated cystatin C levels were significantly associated with the risk of acute kidney injury OR = 2.86 (1.316.23), p < 0.05. Receiver operating characteristic curve analysis demonstrated that cystatin C had predictive value for acute kidney injury, with an area under the curve of 0.655 (0.538-0.772), p = 0.011. The optimal cut-off value of cystatin C was 1.55 mg/L, with a sensitivity of 71.9% and a negative predictive value of 80.8%. Conclusion: Cystatin C is a valuable biomarker for the prediction of acute kidney injury in patients with acute decompensated heart failure.
Keywords
Serum cystatin C, acute kidney injury, acute decompensated heart failure
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