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Issue: No. 102 (2026)
Section: Article
DOI: 10.58490/ctjump.2026i102.4816
Date Published: 25/08/2026
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Ngo, C. N., Pham, T. N. N., Kha, H. N., & Nguyen, T. D. (2026). RESEARCH ON THE rs501120 POLYMORPHISM IN THE CXCL12 GENE AND SOME FACTORS ASSOCIATED WITH CORONARY ARTERY LESIONS IN PATIENTS WITH CHRONIC CORONARY SYNDROME AT SEVERAL HOSPITALS IN CAN THO, 2024-2026. Cantho Journal of Medicine and Pharmacy, 102, 261-267. https://doi.org/10.58490/ctjump.2026i102.4816

RESEARCH ON THE rs501120 POLYMORPHISM IN THE CXCL12 GENE AND SOME FACTORS ASSOCIATED WITH CORONARY ARTERY LESIONS IN PATIENTS WITH CHRONIC CORONARY SYNDROME AT SEVERAL HOSPITALS IN CAN THO, 2024-2026

Cong Nghiep Ngo1, Thi Ngoc Nga Pham1, Huu Nhan Kha1, Thi Diem Nguyen1,
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Coronary artery disease is the leading cause of death worldwide. In addition to traditional risk factors, genetic factors play a significant role in the mechanisms of atherosclerosis and coronary artery disease. The rs501120 polymorphism of the CXCL12 gene is considered to be associated with coronary artery damage. Objectives: To investigate the characteristics of the rs501120 polymorphism of the CXCL12 gene and to evaluate factors associated with the severity of coronary artery lesions in patients with chronic coronary syndrome. Materials and methods: A cross-sectional descriptive study was conducted on 84 patients diagnosed with chronic coronary syndrome who underwent coronary angiography at Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital between 2024 and 2026. Results: The genotype frequencies for the rs501120 polymorphism in the significant stenosis group were CC: 7.1%, CT: 23.8%, and TT: 69%; the TT genotype was identified as an independent factor associated with coronary artery lesions based on the Gensini score with p = 0.043. Smoking (p = 0.001), hypertension (p = 0.029), obesity (p = 0.019), and a family history of premature cardiovascular disease (p < 0.001) were statistically significantly associated with significant coronary artery stenosis. Conclusion: The TT genotype of the rs501120 polymorphism is independently associated with coronary artery lesions as assessed by the Gensini score. 

Keywords

CXCL12, rs501120, chronic coronary syndrome, coronary artery lesions

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