REVIEW OF THE MORPHOLOGY, CHEMICAL CONSTITUENTS, AND PHARMACOLOGICAL ACTIVITIES OF Cissus SPECIES IN VIETNAM
Main Article Content
Abstract
Background: The Cissus genus, belonging to the family Vitaceae, comprises approximately 350 species distributed across tropical and subtropical regions, and is widely utilized in traditional medicine. Several species, such as Cissus quadrangularis, Cissus repens, and Cissus verticillata, have been the subject of numerous international studies and are incorporated into pharmaceutical formulations. In Vietnam, 15 species of the genus Cissus have been identified, among these species, Cissus modeccoides, being commonly cultivated and traditionally used in medicinal preparations. Objectives: To summarize and analyze information regarding the botanical classification, phytochemistry, and pharmacological activities of Cissus species found in Vietnam. Results: Phytochemical investigations of Cissus species have led to the isolation of various classes of compounds, including flavonoids, triterpenoids, stilbene derivatives, phenolic acids, saponins, phytosterols, and alkaloids. The pharmacological profiles of these species demonstrate a range of biological activities such as analgesic, antipyretic, anti-inflammatory, antibacterial, antifungal, antioxidant, hypoglycemic, and cytotoxic effects against cancer cells. Conclusions: These findings underscore the potential of the genus Cissus as a valuable source for further in-depth research in the fields of botany, phytochemistry, and pharmacology.
Keywords
Cissus, morphology, chemical constituents, pharmacological activities
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References
2. Phạm Hoàng Hộ. Cây cỏ Việt Nam, quyển 2. Nhà xuất bản trẻ. 2000. 464-467.
3. Drobnik J. and A. B. de Oliveira. Cissus verticillata (L.) Nicolson and CE Jarvis (Vitaceae): Its identification and usage in the sources from 16th to 19th century. Journal of Ethnopharmacology. 2015. 171 317-329. doi: 10.1016/j.jep.2015.06.003.
4. Beltrame F., A. Ferreira and D. Cortez. Coumarin glycoside from Cissus sicyoides. Natural Product Letters. 2002. 16 (4), 213-216. doi: 10.1080/10.575630290015736.
5. Xu F., H. Matsuda, H. Hata, K. Sugawara, S. Nakamura, et al. Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chemical and Pharmaceutical Bulletin. 2009. 57 (10), 1089-1095. doi: 10.1248/cpb.57.1089.
6. Thakur A., V. Jain, L. Hingorani and K. Laddha. Improved high-performance liquid chromatographyDAD method for the simultaneous analysis of quercetin and kaempferol in the stems of Cissus quadrangularis Linn. Acta Chromatographica. 2009. 21 (1), 95-103. doi: 10.1556/achrom.21.2009.1.8.
7. Ahmadu A., A. Onanuga and R. Aquino. Flavonoid glycosides from the leaves of Cissus ibuensis Hook (Vitaceae). African Journal of Traditional, Complementary and Alternative Medicines. 2010. 7 (3), 225-230. doi: 10.4314/ajtcam.v7i3.54780.
8. Hồ Đức Tài and T. T. V. A. Trần Duy Hiền. Megastigmane, alkaloid, flavonoid, and phenolic compounds from Cissus trilobus (Lour.) Merr. Tạp chí Dược liệu. 2024. 29 (3), 149-153. doi:
9. Saifah E., C. J. Kelley and J. D. Leary. Constituents of the leaves of Cissus rheifolia. Journal of Natural Products. 1983. 46 (3), 353-358. doi: 10.1021/np50027a010.
10. Eswaran R., A. Anandan, A. Doss, G. Sangeetha and S. Anand. Analysis of chemical composition of Cissus quadrangularis Linn by GC-MS. Asian j Pharm Clin Res. 2012. 5 (2), 139-40. doi: https://api.semanticscholar.org/CorpusID:96965115
11. Sen M. K. and B. K. Dash. A review on phytochemical and pharmacological aspects of Cissus quadrangularis L. International Journal of Green Pharmacy (IJGP). 2012. 6 (3). doi: 10.4103/0973-8258.104924.
12. Adesanya S. A., R. Nia, M.-T. Martin, N. Boukamcha, A. Montagnac, et al. Stilbene derivatives from Cissus quadrangularis. Journal of Natural Products. 1999. 62 (12), 1694-1695. doi: 10.1021/np9902744.
13. Mehta M., N. Kaur and K. Bhutani. Determination of marker constituents from Cissus quadrangularis Linn. and their quantitation by HPTLC and HPLC. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques. 2001. 12 (2), 91-95. doi: 10.1002/pca.569.
14. Gupta M. M. and R. K. Verma. Lipid constituents of Cissus quadrangularis. Phytochemistry. 1991. 30 (3), 875-878. doi: 10.1016/0031-9422(91)85270-A.
15. Tiwari M., P. S. Gupta and N. Sharma. Ethnopharmacological, Phytochemical and Pharmacological review of Plant Cissus quadrangularis L. Research Journal of Pharmacognosy and Phytochemistry. 2018. 10 (1), 81-90. doi: 10.5958/0975-4385.2018.00014.6
16. Singh G., P. Rawat and R. Maurya. Constituents of Cissus quadrangularis. Natural Product Research. 2007. 21 (6), 522-528. doi: 10.1080/14786410601130471.
17. Yuan Wang, Zhao Rui Zhang and Hongping He. Stilbene C-glucosides from Cissus repens. Journal of Asian Natural Products Research. 2007. 9 (7), 631-636. doi: 10.1080/10286020600979548.
18. Jainu M. and C. S. Devi. In Vitro and In Vivo Evaluation of Free-Radical Scavenging Potential of Cissus quadrangularis. Pharmaceutical Biology. 2005. 43 (9), 773-779. doi: 10.1080/13880200500406636.
19. Nocedo-Mena D., M. González-Ferrara and M. del Rayo Camacho-Corona. Analysis of chemical composition of Cissus incisa leaves by GC/MS. MOL2NET. 2018. 2 (14), 1-4. doi: 10.3390/mol2net-04-06142.
20. Singaravadivel C. and J. Santhanaraj. Gas chromatography and mass spectroscopic determination of phytocompounds in Cissus vitiginea leaf. Der Pharmacia Lettre. 2016. 8 292-297.
21. Thakur A., V. Jain, L. Hingorani and K. Laddha. Phytochemical studies on Cissus quadrangularis Linn. Pharmacognosy Research. 2009. 1 (4). doi: https://api.semanticscholar.org/CorpusID:93201193.
22. Kumar P., K. Dev, K. Sharma, M. Sahai and R. Maurya. New lignan glycosides from Cissus quadrangularis stems. Natural Product Research. 2019. 33 (2), 233-238. doi: 10.1080/14786419.2018.1443099.
23. Das R., S. Kolhe, A. Patil, K. Wadher and M. Umekar. Development and evaluation of transdermal patches with Cissus quadrangularis plant extract. Int. J. Life science and Pharma Res. 2018. 8 (2).
24. Chan Y.-Y., C.-Y. Wang, T.-L. Hwang, S.-H. Juang, H.-Y. Hung, et al. The constituents of the stems of Cissus assamica and their bioactivities. Molecules. 2018. 23 (11), 2799. doi: 10.3390/molecules23112799.
25. Dutta T., A. Paul, M. Majumder, R. A. Sultan and T. B. Emran. Pharmacological evidence for the use of Cissus assamica as a medicinal plant in the management of pain and pyrexia. Biochemistry and Biophysics Reports. 2020. 21 100715. doi: 10.1016/j.bbrep.2019.100715.
26. Sáenz M., M. Garcia, A. Quilez and M. Ahumada. Cytotoxic activity of Agave intermixta L. (Agavaceae) and Cissus sicyoides L. (Vitaceae). Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2000. 14 (7), 552-554. doi: 10.1002/1099-1573(200011)14:7<552::aid-ptr639>3.0.co;2-u.
27. Subramani B. Analysis of potential toxicological, phytochemical and anticancer properties from Cissus quandrangularis. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. 2018. 4 (3), 94-105. doi: 10.26479/2018.0403.08.
28. Dhanasekaran S. Phytochemical characteristics of aerial part of Cissus quadrangularis (L) and its in-vitro inhibitory activity against leukemic cells and antioxidant properties. Saudi Journal of Biological Sciences. 2020. 27 (5), 1302-1309. doi: 10.1016/j.sjbs.2020.01.005.
29. Suresh P., A. S. Xavier, V. Karthik and K. Punnagai. Anticancer activity of Cissus quadrangularis L. methanolic extract against MG63 Human Osteosarcoma cells–An in-vitro evaluation using cytotoxicity assay. Biomedical and Pharmacology Journal. 2019. 12 (2), 975980. doi: 10.13005/bpj/1724.
30. Mishra G., S. Srivastava and B. Nagori. Pharmacological and therapeutic activity of Cissus quadrangularis: an overview. International Journal of Pharmtech Research. 2010. 2 (2). 1298-1310.
31. Huỳnh Minh Đạo and Bùi Mỹ Linh. Khảo sát độc tính cấp, tác dụng chống viêm và hạ đường huyết của cây Hồ đằng rễ mành (Cissus verticillata (L.) Nicolson & Jarvis). TNU Journal of Science and Technology. 2025. 230 (05), 246 - 253.
32. Beltrame F. L., G. L. Pessini, D. L. Doro, B. P. Dias Filho, R. B. Bazotte, et al. Evaluation of the antidiabetic and antibacterial activity of Cissus sicyoides. Brazilian Archives of Biology and Technology. 2002. 45 21-25.doi: 10.1590/S1516-89132002000100004.