ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ Ở TRẺ 6-60 THÁNG MẮC TIÊU CHẢY CẤP DO ROTAVIRUS CÓ SỬ DỤNG RACECADOTRIL TẠI BỆNH VIỆN NHI ĐỒNG THÀNH PHỐ CẦN THƠ NĂM 2025-2026

Abstract

Background: Acute diarrhea caused by Rotavirus is a common cause of hospitalization in young children. Racecadotril has been used as supportive treatment for acute diarrhea; however, findings across studies remain inconsistent, and data from the Can Tho region are limited. Objectives: To describe the clinical and paraclinical characteristics and to compare selected treatment outcomes between children with acute Rotavirus diarrhea who received racecadotril and those who did not. Materials and methods: A prospective observational cohort study with a comparison group was conducted on 87 children aged 6–60 months with acute Rotavirus diarrhea at Can Tho Children’s Hospital from April 2025 to January 2026. Clinical, paraclinical, and treatment outcome data were collected using a standardized study form. Rotavirus infection was confirmed by a positive ROTACHECK-1 rapid test. Data were analyzed using SPSS 18.0. The Mann–Whitney U test and independent-samples t-test were used, with statistical significance set at p<0.05. Results: Among 87 children, the 12–<24-month age group accounted for the highest proportion (67.8%). Forty-five children (51.7%) received racecadotril, while 42 children (48.3%) did not. The racecadotril group had a lower number of diarrheal episodes within 48 hours than the non-racecadotril group, with medians of 8 versus 9 episodes, respectively (p=0.046); a lower total volume of intravenous fluid, 360 mL versus 500 mL (p=0.011); and a shorter hospital stay, 5.31 ± 0.23 days versus 6.61 ± ROTA 0.23 days (p<0.001). No statistically significant differences were observed between the two groups in the number of vomiting episodes within 48 hours, duration of diarrhea, or duration of vomiting. Conclusion: Acute Rotavirus diarrhea mainly occurred in children aged 12–<24 months. Children who received racecadotril had fewer diarrheal episodes within 48 hours, lower intravenous fluid requirements, and shorter hospital stays than those who did not. Racecadotril may be con-sidered a supportive treatment option for acute Rotavirus diarrhea in children.