VALUE OF D-DIMER AND THE NEWS2, PSI, CURB-65 SCORES IN DIAGNOSING SEVERITY AND PREDICTING 30-DAY MORTALITY IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA
Main Article Content
Abstract
Background: Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. Early identification of severe disease and accurate risk stratification are essential to determine the appropriate level of care. Objectives: To describe and analyze the value of D-dimer and the NEWS2, PSI, and CURB-65 scoring systems in identifying severe CAP and predicting 30-day mortality. Materials and methods: We conducted a prospective observational cohort study of adult patients diagnosed with CAP at Can Tho Central General Hospital between 2024 and 2026. The performance of variables was evaluated using the area under curve (AUC), standardized odds ratio (SOR), calibration, and prediction error (Brier score). Results: For severity assessment, NEWS2 showed the highest AUC (0.902) and the lowest Brier score (0.088). For 30-day mortality prediction, PSI had the highest AUC (0.881) and the lowest Brier score (0.129). In univariate logistic regression analysis, NEWS2 showed the strongest association with severe disease (SOR = 8.27), while D-dimer showed the strongest association with 30day mortality (SOR = 10.41). All scores and D-dimer demonstrated good calibration. Conclusion: NEWS2 appears useful for early assessment of disease severity. For 30-day mortality, PSI may be used for risk stratification, while D-dimer may serve as a promising prognostic biomarker.
Keywords
Community-acquired pneumonia, D-dimer, NEWS2, PSI, CURB-65
Article Details
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