OPTIMIZATION OF SPRAY DRYING CONDITIONS FOR RED FO-TI (FALLOPIA MULTIFLORA (THUNB.)) EXTRACT AT LABORATORY SCALE
Main Article Content
Abstract
Background: Fallopia multiflora (Thunb.) is a traditional medicinal herb widely used in Asian countries. It contains abundant polyphenolic compounds with significant biological activities but also poses a potential risk of hepatotoxicity. Appropriate processing can help reduce toxicity and produce a stable and safe dry extract. Objective: To prepare a spray-dried powder extract from the roots of Fallopia multiflora with optimized characteristics. Materials and methods: Spray-drying conditions were optimized using Modde Pro 12 software. Independent variables included the maltodextrin: Aerosil 200 ratio (X1, 0–40%), inlet air temperature (X2, 100–130°C), and feed flow rate (X3, 1.5–2.5 mL/min). Dependent variables were powder properties, dry extract yield, and total polyphenol content (TPC) recovery. Results: Based on the desirability function, the optimal conditions were: extract concentration 3:1; Aerosil 200 as excipient; solid content of the feed solution 2%; atomizing air pressure 2 bar; feed flow rate 1.5 mL/min; inlet temperature 100 ± 2°C; using a Mini Spray-Dryer B-191 (Switzerland). Under these conditions, the obtained dry extract exhibited suitable properties, with a yield of 63.99% and TPC recovery of 52.26% (at 100 g liquid extract per batch), consistent with the predicted values. Conclusion: Experimental design methodology is an effective tool for investigating and optimizing spray-drying conditions of Fallopia multiflora extract at laboratory scale.
Keywords
Dry extract, Fallopia multiflora, spray-drying, optimization
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References
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