CLINICAL CHARACTERISTICS, SOME FACTORS RELATED TO CHEMICAL DISEASE AT CAN THO DERMATO-VENEREOLOGY HOSPITAL IN 2024-2025

Thanh Lam1, , Gia Hung Tran1, Van Sang Huynh1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Melasma is a chronic acquired pigmentation disorder that affects aesthetics, particularly in women. Its etiology is complex, involving environmental, hormonal, and cellular factors. Clinically, melasma is characterized by well-defined light to dark brown or gray-brown patches, mainly on the face, especially on both cheeks. Although it does not pose a serious health risk, melasma can negatively impact patients' psychology and quality of life. Objective: To describe the clinical characteristics and associated factors of melasma at Can Tho Dermato-Venereology Hospital in 2024-2025. Materials and methods: A cross-sectional descriptive study was conducted on 30 patients at Can Tho Dermato-Venereology Hospital. Results: The mean age of onset was 47.67 ± 4.999 years, with 100% of cases occurring in women. Occupational distribution: traders (43.3%), housewives (26.7%), office workers (23.3%), and laborers (6.7%). Clinical types: butterfly pattern (73.3%), centrofacial (16.7%), and indeterminate (10%). Melasma severity based on the MASI score: moderate (20%), severe (66.7%), and very severe (13.3%). Related factors: skin type III (50%) and IV (50%); sun exposure > 60 minutes (43.3%); Improper mask use (56.7%); Lack of wide-brimmed hat use (76.7%); Improper or no sunscreen use (40% each). Frequent cosmetic use (40%), oral contraceptive use (60%), history of pregnancy-related melasma (50%), and family history (16.7%). A statistically significant correlation was found between melasma severity (MASI score) and sun exposure, protective habits, oral contraceptives, and menstrual cycles (p<0.05). Conclusion: Melasma has distinct clinical features, and its severity is influenced by multiple endogenous and exogenous factors. 

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References

1. Bộ Y Tế. Rám má. Hướng dẫn chẩn đoán và điều trị một số bệnh Da liễu. 2023, 410-415.
2. Nguyễn Trọng Hào. Rám da. Hướng dẫn chẩn đoán và điều trị bệnh Da liễu. 2019, 208-216.
3. Lê Thái Vân Thanh. Laser pico giây Nd:YAG 1064nm trong điều trị rám má. Tạp chí Y học Việt Nam. 2023. 530, 391-395.
4. Lê Thị Thu Hải, Bùi Thị Thu Phương, Nguyễn Thị Linh Lan. Đánh giá kết quả điều trị nám má bằng laser pico giây tại Bệnh viện Trung ương Quân đội 108. Journal of 108 - clinical medicine and pharmacy. 2020, 15.
5. Fabi S.G., Friedmann D.P., Niwa Massaki A.B., Goldman M.P. A randomized, split‐face clinical trial of low‐fluence Q‐switched neodymium‐doped yttrium aluminum garnet (1,064 nm) laser versus low‐fluence Q‐switched alexandrite laser (755 nm) for the treatment of facial melasma. Lasers in surgery and medicine. 2014. 46(7), 531-537. DOI:10.1002/lsm.22263
6. Wong C.S.M., Chan M.W.M., Shek S.Y.N., Yeung C.K., Chan H.H.L. Fractional 1064 nm picosecond laser in treatment of melasma and skin rejuvenation in Asians, a prospective study. Lasers in Surgery and Medicine. 2021. 53(8), 1032-1042. DOI: 10.1002/lsm.23382
7. Lê Minh Hoài, Huỳnh Văn Bá. Đánh giá kết quả điều trị bệnh rám má bằng Laser Q-Switched ND:YaG kết hợp bôi FOB Tri-White Serum tại Bệnh viện Trường Đại học Y Dược Cần Thơ năm 2019-2020. Luận Văn chuyên khoa II. Trường Đại học Y Dược Cần Thơ. 2021.
8. Choi Y.J., Nam J.H., Kim J.Y., Min J.H., Park K.Y., et al. Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split‐face, 2% hydroquinone cream‐controlled clinical trial. Lasers in surgery and medicine. 2017. 49(10), 899-907. DOI: 10.1002/lsm.22735
9. Grimes P.E. Melasma: Etiologic and therapeutic considerations. Archives of dermatology. 1995. 131(12), 1453-1457. DOI: 10.1001/archderm.131.12.1453
10. Lê Thái Vân Thanh. Nghiên cứu rám má trên phụ nữ có thai và một số biện pháp can thiệp. Luận án tiến sĩ Y học Đại học Y Hà Nội. 2015.
11. Ortonne J.P., Arellano I., Berneburg M., Cestari T., Chan H., et al. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melisma. J Eur Acad Dermatol Venereol. 2009. 1254-1262. DOI: 10.1111/j.1468-3083.2009.03295.x.