KHẢ NĂNG HỢP LỰC CỦA CAO PHÂN ĐOẠN TRÂM TRÒN, XĂNG MÃ CÒ KE TRÊN HOẠT TÍNH KHÁNG MRSA ATCC33591

Abstract

Background: Antibiotic is a special class of drugs of which the use affects not only the patient but also the community. In Viet Nam, antibiotic is an important class of drugs because infectious diseases in Viet Nam is the top ratio of infections and death. MRSA accounted for 82.1% of all isolates of S. aureus as the cause of death related to hospital-acquired pneumonia. Objective: The synergistic formulations of the ethylacetate of Syzygium glomeratum G., Carallia brachiata L., and Grewia asiatica L extracts together on anti-MRSA activity are going to determine. Materials and methods: The diffusion method and the dilution method are used to determine of anti-MRSA activity of plant ethanol extracts and fractions. The SRB assay is used to determination of the safety of plant ethanol extracts on two cell lines of fibroblasts and liver cancer cells. The FIC index was calculated based on the checkerboard method to determine the synergistic ability of the ethyl acetate fractions together on the anti-MRSA activity. Results: Finally, the synergistic formulation of ethyl acetate of Syzygium glomerulatum G. and Carallia brachiata L is 0.008mg/mL and 0.625 mg/mL; the synergistic formulation of ethyl acetate of Syzygium glomerulatum G. and Grewia asiatica L. is 0.063 mg/mL and 0.126 mg/mL. Conclusion: The anti-MRSA activity of Syzygium glomerulatum G., Carallia brachiata L., and Grewia asiatica L extracts are assessed, and these synergistic formulas were reported for the first time.