EVALUATION OF PREGNANCY OUTCOMES IN DIABETIC PREGNANT WOMEN TREATED WITH INSULIN AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL IN 2021-2023

Thi Lan Anh Pham1, Kim Ngan Ly1, Thuc Vi1, Kim Thoa Bui1, Ho Bao Tram Nguyen1, Nguyen Nha Truc Lam1, Tin Nghia Tran1,
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Diabetes during pregnancy is recognized as a major risk factor for increased obstetric complications. Insulin therapy is indicated when medical nutrition therapy fails to achieve glycemic targets, aiming to mitigate risks for both mother and fetus. Objectives: To evaluate pregnancy outcomes in women with diabetes (including pre-gestational and gestational diabetes) treated with insulin at Can Tho Obstetrics and Gynecology Hospital. Materials and methods: A retrospective cross-sectional study was conducted on 137 women with singleton pregnancies diagnosed with diabetes requiring insulin who delivered at Can Tho Obstetrics and Gynecology Hospital from January 2021 to January 2023. Results: The highest proportion of patients was aged >35 years (54.0%). Regarding adverse obstetric history, a history of macrosomia accounted for 27.7%. Optimal glycemic control was achieved in 65.7% of cases. Postpartum insulin use was recorded in 49.6% of participants. Most pregnancies reached a gestational age of ≥37 weeks (67.2%). Spontaneous labor was the primary reason for the end of pregnancy (89.1%). The cesarean section rate was remarkably high (93.4%). The most frequent complication was large-forgestational-age (LGA) fetuses (53.3%). Other maternal and fetal complications included preterm birth (32.8%), stillbirth (4.4%), and polyhydramnios (16.8%). Low Apgar scores <7 at 1 and 5 minutes were recorded in 4.6% and 3.8% of neonates, respectively. Four cases of neonatal hypoglycemia occurred. Conclusions: Insulin-treated diabetes in pregnancy is associated with high obstetric risks. While the majority of patients underwent cesarean delivery and achieved optimal glycemic control by the end of pregnancy (65.7%), the incidences of complications such as preterm birth, LGA (macrosomia), and stillbirth remain high. 

Article Details

References

1. ACOG. Gestational Diabetes Mellitus: ACOG Practice Bulletin No. 190. Obstetrics & Gynecology. 2018. 131(2), e49–e64. https://doi.org/10.1097/AOG.0000000000002501.
2. ADA. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes–2021. Diabetes Care. 2021. 44 (Supplement 1), S200–S210. https://doi.org/10.2337/dc21-S014.
3. Behboudi-Gandevani S, Bidhendi-Yarandi R, Panahi MH, Vaismoradi M. The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis. Frontiers in Endocrinology. 2021. 12:640004, https://doi.org/10.3389/fendo.2021.640004.
4. Guo L, Ma J, Tang Z, Zhang W. Association between treatment of gestational diabetes mellitus and pregnancy outcomes: A meta-analysis. Journal of Clinical Medicine. 2021. 10(9), 1934. https://doi.org/10.3390/jcm10091934.
5. Tola A., Assefa N., Dessie Y., Oljira L., Regassa L. D., Gure T., Gobena T. Epidemiology of hyperglycemia during pregnancy in Ethiopia: prevalence, associated factors, and feto-maternal outcomes: systematic review and meta-analysis. Systematic Reviews. 2024. 13(1),116, https://doi.org/10.1186/s13643-024-02526-z.
6. Võ Thị Thành, Nguyễn Minh Tài Lộc, Vương Thị Ngọc Lan. Kết cục thai kỳ các trường hợp đái tháo đường thai kỳ điều trị insulin chấm dứt thai kỳ tại Bệnh viện Từ Dũ. Tạp chí Y Học TP. Hồ Chí Minh. 2019, 23(2), 63-68. https://tapchiyhoctphcm.vn/articles/16947.
7. Phan Virakthida, Hà Hữu Hoàng Khải, Phạm Bá Nha. Xử trí sản khoa các sản phụ đái tháo đường điều trị insulin tại Bệnh viện Bạch Mai. Tạp chí Y học Việt Nam. 2025. 546(1), 314-317, https://doi.org/10.51298/vmj.v546i1.12556.
8. Trần Quang Hanh, Bùi Sơn Thắng, và Trọng Tài Lê. So sánh đặc điểm lâm sàng, cận lâm sàng giữa nhóm sản phụ đái tháo đường thai kỳ điều trị tiết chế và điều trị Insulin tại Bệnh viện Sản Nhi Nghệ An năm 2023. Tạp Chí Y học Việt Nam. 2024. 537(1), 133-137, https://doi.org/10.51298/vmj.v537i1.9009.
9. Bộ Y tế. Hướng dẫn quốc gia dự phòng và kiểm soát đái tháo đường thai kỳ. 2018. https://benhvienhatrung.vn/wp-content/uploads/2022/09/6173-2018-HDQG-Dai-thao-duongthai-ky-20.10.2018.pdf.
10. Huỳnh Thanh Phong, Nguyễn Minh Anh, Nguyễn Thị Diễm Thuý, Đào Thuý Anh, và Nguyễn Thế Bảo. Một số yếu tố nguy cơ của đái tháo đường thai kỳ: nghiên cứu bệnh chứng. Tạp Chí Y học Việt Nam. 2024. 541(1), https://doi.org/10.51298/vmj.v541i1.10683.
11. Nguyễn Thị Kim Anh. Nghiên cứu các yếu tố liên quan và kết cục thai kỳ ở phụ nữ đái tháo đường trong thai kỳ. Tạp chí Y Dược Huế. 2018. 8(5), 108-114, https://www.doi.org/10.34071/jmp.2018.5.16.
12. Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes research and clinical practice. 2022. 183, 109119, https://doi.org/10.1016/j.diabres.2021.109119.
13. Zhou X., Zhang R., Jiang S., Cheng D., & Wu H. Analysis glycemic variability in pregnant women with various type of hyperglycemia. BMC pregnancy and childbirth. 2025. 25(1), 454, https://doi.org/10.1186/s12884-025-07513-3.
14. American Diabetes Association Professional Practice Committee. 15. Management of diabetes in pregnancy: Standards of care in diabetes—2025. Diabetes Care. 2025. 48(Supplement_1), S306–S320, https://doi.org/10.2337/dc25-S015.
15. Nguyễn Thị Việt Chinh, Nguyễn Khoa Diệu Vân. Đặc điểm lâm sàng, cận lâm sàng và các yếu tố liên quan của bệnh nhân đái tháo đường mang thai. Tạp Chí Y học Việt Nam. 2020. 521(2), 60-64, https://doi.org/10.51298/vmj.v521i2.4042.