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THE VALUE OF KINETIC ESTIMATED GLOMERULAR FILTRATION RATE IN THE PROGNOSIS OF ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE PANCREATITIS
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Abstract
Background: Acute kidney injury is one of the common serious complications in patients with severe acute pancreatitis and is assessed based on changes in serum creatinine. Kinetic estimated glomerular filtration rate (KeGFR) is a surrogate index for monitoring and diagnosing acute kidney injury in the early stage of acute pancreatitis. Objectives: To determine the rate of acute kidney injury and the value of KeGFR in the prognosis of acute kidney injury in patients with acute pancreatitis. Materials and methods: A cross-sectional descriptive study analyzed 130 patients diagnosed with acute pancreatitis admitted to Can Tho Central General Hospital. Results: The rate of acute kidney injury in patients with acute pancreatitis was 16.9%, stage 1 accounting for the majority (59.1%). The KeGFR cut-off value on day 2 was 82.1 mL/min/1.73 m2 (sensitivity 86.4% and specificity 83%) with an area under the curve at a very good threshold for early diagnosis of acute kidney injury (AUC = 0.902), KeGFR on day 3 with a cut-off point of 83.05 mL/min/1.73 m2 allowed the diagnosis of acute kidney injury with an area under the curve AUC = 0.849, sensitivity 77% and specificity 88%. Conclusion: KeGFR is an index for monitoring and evaluation the kidney function, and a valuable marker in the prognosis of acute kidney injury in the early stages of acute pancreatitis.
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Keywords
Acute kidney injury, Acute pancreatitis, Kinetic estimated glomerular filtration rate
References
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