ĐẶC ĐIỂM RỐI LOẠN ĐÔNG MÁU VÀ MỐI TƯƠNG QUAN VỚI NỒNG ĐỘ LACTATE MÁU Ở BỆNH NHÂN SỐC NHIỄM TRÙNG TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ NĂM 2023-2024

Abstract

Background: While a few studies have demonstrated the association between coagulation disorders and elevated blood lactate levels in critically ill patients, most coagulation parameters commonly used are nonspecific standalone markers. Few studies have explored the correlation between coagulation indices and blood lactate levels in patients with septic shock. Objective: To describe the characteristics of coagulation disorders and their correlation with blood lactate levels in patients with septic shock at Can Tho Central General Hospital from 2023 to 2024. Materials and methods: A cross-sectional descriptive study was conducted on 100 patients with septic shock (Sepsis3 2016). Results: The mean age was 64.22 ± 16.62 years, with an approximately equal male-to-female ratio. The rate of clinical bleeding was 28%, and 36% of patients had disseminated intravascular coagulation (DIC). The mean blood lactate level was 6.46 ± 4.42 mmol/L. Prothrombin time percentage (%PT) was weakly negatively correlated with blood lactate levels (r = -0.248, p = 0.013). Conversely, international normalized ratio (INR) and activated partial thromboplastin time (aPTT) showed weak positive correlations with blood lactate levels (r = 0.293, p = 0.003 and r = 0.294, p = 0.003). Conclusion: Coagulation disorders are common in patients with septic shock. Specifically, approximately one-fourth of patients exhibited clinical bleeding, and most had abnormal coagulation test results, with about one-third meeting criteria for DIC. Additionally, weak correlations were observed between %PT, INR, aPTT, and blood lactate levels.