SYNTHESIS AND EVALUATION OF ANTICANCER ACTIVITY OF NOVEL ANTHRANILAMIDE DERIVATIVES
Main Article Content
Abstract
Background: Research on new anticancer derivatives is becoming necessary worldwide. Approach to developing new cancer drugs, The study of anthranilamide derivatives is focused on amino substituent and aromatic amide and evaluates their anticancer activities. Objectives: Synthesis and evaluation of anticancer activities of novel anthranilamide derivatives. Materials and method: Synthesize anthranilamide derivatives by substitution reactions, oxidation, reduction, and EDC coupling reactions. Determine the structures by IR, MS, and NMR spectroscopy. The cancer cell cytotoxic activity was evaluated by MTT assay on the A549 lung cancer cell line and MCF-7 breast cancer cell line. Results: Three novel anthranilamide derivatives (8a, 8b, 8c) were synthesized and spectroscopy methods confirmed their structures. The results of the cytotoxicity assay showed that only the derivative 8c exhibited cytotoxic activity on these cancer cell lines with the IC50 value of 114,2 ± 4,43 and 117,86 ± 0,75 µg/mL on lung cancer cell line A549 and breast cancer cell line MCF-7 respectively. Conclusions: Three anthranilamide derivatives were synthesized and evaluated for their anticancer activities.
Keywords
anthranilamide, synthesis, anticancer, cytotoxicity
Article Details
References
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