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EVALUATION OF THE IN VITRO ANTIOXIDANT ACTIVITY OF SOME ARTICHOKE PREPARATIONS USING THE DPPH ASSAY
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Abstract
Background: Artichoke (Cynara scolymus L.) is a medicinal plant prioritized for strategic development and investment in Vietnam. Its chemical composition is predominantly polyphenols, which have been demonstrated to exhibit strong antioxidant activity. In both domestic and foreign markets, numerous preparations containing artichoke leaf extracts available in various formulations. However, some studies indicate significant differences in polyphenol content among these formulations, which may influence their pharmacological effects. Objectives: To evaluate the antioxidant activity of artichoke preparations in vitro model using the DPPH assay. Materials and methods: 19 Artichoke preparations were collected from the domestic and foreign markets. Antioxidant activity was evaluated by DPPH free radical scavenging method. Results: There was a correlation between the concentration and antioxidant activity of the test samples with a correlation coefficient R² ranging from 0.984 to 0.998. Foreign formulations N.CP (1-8) had higher antioxidant activity than domestic formulations V.CP (8-16), except for formulations V.CP11, V.CP14-16. Conclusions: Antioxidant activity and IC50 (µg/mL) of 19 formulations were investigated compared to positive controls vitamin C and silymarin. The results indicate that most foreign formulations exhibit moderate antioxidant activity, while domestic formulations vary significantly in quality, ranging from no effect to relatively high activity.
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Keywords
Artichoke, antioxidant, Cynara scolymus, DPPH, polyphenol
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