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STUDYING THE LIVER PROTECTIVE EFFECT OF PYCNOPORUS SANGUINEUS STANDARDIZED EXTRACT CONTAIN PHENOLIC COMPOUNDS ON EXPERIMENTAL ANIMALS
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Abstract
Background: Pycnoporus sanguineus protects the liver against oxidative damage. However, the standardized extract of the components related to the liver-protective effect in this medicinal herb has not been studied, nor has there been any study evaluating the pharmacological effects of the Pycnoporus sanguineus standardized extract containing phenolic compounds related to the liver-protective effect. Objectives: To evaluate the hepatoprotective effect of standardized extract contain phenolic compounds from Pycnoporus sanguineus on experimental animals. Materials and methods: The Pycnoporus sanguineus standardized extract containing phenolic compounds investigated hepatoprotective effects on hepatoxicity model induced by paracetamol in mice. Results: The Pycnoporus sanguineus standardized extract containing phenolic compounds at the dose of 500 mg/kg and 1000 mg/kg significantly decreased plasma AST, ALT, MDA levels, increased GSH contents in mice liver homoganates and improved damage in both macroscopic and microscopic mice liver. Conclusion: The Pycnoporus sanguineus standardized extract containing phenolic compounds has the effect of supporting hepatoprotective in the model of acute liver injury with paracetamol.
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Keywords
Standardized extract, Pycnoporus sanguineus, hepatoprotective
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