KHẢO SÁT TƯƠNG TÁC THUỐC TẠI KHOA HỒI SỨC TÍCH CỰC - CHỐNG ĐỘC TẠI MỘT BỆNH VIỆN HẠNG I

Abstract

Background: Drug-drug interactions (DDIs) often occur in clinical practice, which can cause serious consequences, especially in patients in the intensive care unit (ICU). Objectives: To survey the frequency and severity of DDIs and the risk factors on ICU patients. Materials and methods: A retrospective study was conducted at the ICU, a tertiary hospital with medical records of patients discharged from the ICU from September 2021 to March 2022. DDIs were checked by Micromedex and the List of contraindicated DDIs of the Ministry of Health. Results: Among 121 patients included in the analysis, the average number of medications per day was 4  2.8, the average number of medications for the entire treatment period was 31  12.6. The frequency of DDIs is 120/121 patients (99.2%). The number of DDIs per day per patient is 3  1.8. There were 219 unique pairs of DDIs detected with an average of 10  7.9 pairs per patient. DDIs classified as “contraindicated”, “serious”, and “moderate” occurred in 18.2%, 92.6%, and 86.0% of patients, respectively. The three most commonly contraindicated pairs of DDIs were Fentanyl – Linezolid (33.9%), Ephedrine – Linezolid (14.1%), and Haloperidol – Levofloxacin (9.9%). Cardiovascular drugs appeared in 39.4% of pairs of DDIs. Age, length of stay in the department, average number of drugs each day,  number of drugs in the entire treatment regimen increased the number of DDIs (p < 0.05). Conclusion: DDIs occur commonly with high rates of “serious” and “contraindicated” DDIs in ICU patients. There is a need for intervention strategies to detect, treat and prevent DDIs in ICU.