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Date Published: 18/10/2022
Online Published: 18/10/2022
Abstract Views: 178
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DOI: https://doi.org/10.58490/ctump.2022i52.289
Issue
No. 52 (2022)
Section
Article
How to Cite
Chung, T. N. B., Quach, H. B., & Tran, T. T. T. (2022). SERUM CYSTATIN C CONCENTRATIONS IN PREECLAMPSIA PREGNANT WOMEN AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL. Cantho Journal of Medicine and Pharmacy, 52, 135-141. https://doi.org/10.58490/ctump.2022i52.289

SERUM CYSTATIN C CONCENTRATIONS IN PREECLAMPSIA PREGNANT WOMEN AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL

Thi Ngoc Bich Chung1, Hoang Bay Quach2, Thai Thanh Tam Tran3,
1 1. Phuoc Long District Medical Center
2 2. Can Tho Obstetrics and Gynecology Hospital
3 3. Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Preeclampsia is a pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Serum cystatin C is a novel marker for the early detection of renal damage in pre-eclampsia. Objectives: To determine the average value of renal function indexes and some factors related to serum cystatin C levels in pre-eclamptic pregnant women at Can Tho Obstetrics and Gynecology hospital. Materials and method: A controlled cross-sectional description, study on 2 groups of pregnant women: a group of pregnant women with pre-eclampsia and a group of healthy women who come to give birth or are hospitalized for treatment of diseases related to pre-eclampsiaeclampsia at Can Tho Obstetrics and Gynecology Hospital in 2021-2022. Results: Average maternal age of healthy pregnant women and pre-eclampsia group was respectively 31.3±6.4, 33.5±6.4 years old (p>0.05), gestational age of healthy group and pre-eclampsia group 37.0; 37.1 weeks (p>0.05). Characteristics of urine, kidney function in 2 groups of healthy pregnant women and pre-eclampsia, were respectively: Serum urea 3.0; 3.0mmol/L (p>0.05), serum creatinine 50.7±8.9; 54.5±11.4µmol/L (p>0.05), serum cystatin C 0.85; 1.4mg/L (p<0.01), 24-hour proteinuria 221.3±35.3; 799.5mg/24 hours (p<0.01), 24-hour creatinine clearance of healthy group and pre-eclampsia group groups 153.0; 162.5±62.0mL/min (p>0.05). The correlation between serum creatinine, serum cystatin C, and 24-hour creatinine clearance in pre-eclamptic pregnant women was r1=-0.45 (p<0.01), r2=-0.34 (p<0.05). Conclusions: Serum cystatin C seems to be a promising biomarker for the early detection of renal injury in pre-eclamptic women.

Article Details

Keywords

Serum Cystatin C, preeclampsia

References

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