MỘT SỐ VẤN ĐỀ LIÊN QUAN ĐẾN THUỐC TRONG KÊ ĐƠN HÓA TRỊ LIỆU UNG THƯ TẠI KHOA NỘI MỘT BỆNH VIỆN CHUYÊN KHOA UNG BƯỚU Ở ĐỒNG BẰNG SÔNG CỬU LONG

Abstract

Background: Drug-related problems (DRP) can affect the effectiveness of treatment and the safety of patients, especially with cancer treatment drugs. In Vietnam, there is little data on DRP in cancer patients. Objective: To determine the rate, and types of some drug-related problems in prescribing the first cycles of chemotherapy and factors related to the occurrence of  DRP. Materials and methods: A cross-sectional descriptive study was conducted on medical records of cancer patients receiving chemotherapy at the Internal Medicine Department of an Oncology Hospital in the Mekong Delta, from October 2022 to March 2023. DRP was determined by comparing the drugs used in the medical records to the references. DRPs were then classified according to the guidance of the Ministry of Health in Decision No. 3547/QD-BYT, July 22, 2021. Factors related to  the occurrence of DRP were determined by multivariable logistic regression model. Results: There were 196 medical records included in the study, the mean age of the patients was 56.2 (range 27 - 92), with 76.5% being female. A total of 175 DRPs were recorded across 115 medical records. The rate of medical records with at least one DRP was 58.7%, with an average of 0.9 DRP per medical record. Among the recorded DRPs, the most prevalent were related to dosage (82.3%), with the majority being doses lower than recommended (39.4%) and inappropriate timing of administration (38.9%). DRP related to drug selection accounted for 6.3% and those related to insufficient treatment accounted for 11.4%. Factors including male gender, older age (≥ 65 years old), and late stage (III, IV) increase the risk of DRP appearing. Conclusion: The prevalence of DRP was quite high in prescribing cancer chemotherapy. Appropriate interventions should be carried out to minimize DRP.