NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG VÀ ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ BỆNH NẤM DA DERMATOPHYTES BẰNG SỰ PHỐI HỢP TERBINAFINE THOA VÀ ITRACONAZOLE UỐNG TẠI BỆNH VIỆN DA LIỄU CẦN THƠ VÀ BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2022-2024

Abstract

  Background: Currently, many patients with dermatophytosis are treated with a variety of antifungal drugs but they are ineffective and relapses are common. The combination of antifungal drugs for the treatment of dermatophytosis, including oral itraconazole and topical terbinafine, has been shown to be more effective than monotherapy. However there has not been much research on the effectiveness of this combination treating dermatophytosis in Vietnam. Objectives: To describe the clinical characteristics and evaluate the results of patients with dermatophytosis treated with the combination of oral itraconazole and topical terbinafine at Can Tho Dermato-Venereology Hospital and Can Tho University of Medicine and Pharmacy Hospital from 2022 to 2024. Materials and methods: A cross-sectional descriptive study which included 122 patients who were diagnosed with dermatophytosis was conducted. Clinical characteristics and treatment results of patients were recorded at baseline, second week and fourth week. The study period was from July 2022 to March 2024. Results: The age group of 16 – 30 years old (41.8%) and male gender (60.7%) were the most common in the study. The dominant clinical characteristics were pruritus (97.5%), erythema (100%), scaling (93.4%), central skin atrophy (90.2%), tinea corporis (91.8%), tinea cruris (23%), polycyclic pattern (87.7%) and round pattern (74.6%). The severity scores of the three symptoms and signs (pruritus, erythema and scaling) at the second week and fourth week compared with their baseline value and at fourth week compared with second week were significantly decreased (p<0.05). The cure rate of the patients after the second and fourth weeks of treatment were 36.9% and 87.7% respectively. Conclusion: Pruritus, erythema, scaling, central skin atrophy, tinea corporis, tinea cruris, polycyclic pattern and round pattern were the most common clinical characteristics in dermatophytosis. With the treatment that combined of topical terbinafine and oral itraconazole, symptoms and signs of the disease were significantly reduced.