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Date Published: 25/07/2024
Online Published: 25/07/2024
Abstract Views: 53
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DOI: https://doi.org/10.58490/ctump.2024i76.2638
Issue
No. 76 (2024)
Section
Article
How to Cite
Bui, T. M. L., Le, V. K., & Phan, H. H. (2024). SOME FACTORS RELATED TO THE SEVERITY AND RESULTS OF TREATMENT OF CHILDREN WITH KETOACIDOSIS DUE TO TYPE 1 DIABETES AT CAN THO CHILDREN’S HOSPITAL. Cantho Journal of Medicine and Pharmacy, 76, 132-138. https://doi.org/10.58490/ctump.2024i76.2638

SOME FACTORS RELATED TO THE SEVERITY AND RESULTS OF TREATMENT OF CHILDREN WITH KETOACIDOSIS DUE TO TYPE 1 DIABETES AT CAN THO CHILDREN'S HOSPITAL

Thi My Linh Bui1,, Van Khoa Le1, Huu Hen Phan2
1 Can Tho University of Medicine and Pharmacy
2 Cho Ray Hospital, Ho Chi Minh City

Main Article Content

Abstract

Background: Diabetic ketoacidosis (DKA) is a leading cause of morbidity and mortality in children with type 1 diabetes mellitus (T1DM). Timely diagnosis, comprehensive clinical and biochemical evaluation, and effective management are key to successfully resolving DKA. Objective: Survey some factors related to severity and comment on the treatment results of children with DKA at Can Tho Children's Hospital. Materials and method: A series of cases with 31 pediatric patients diagnosed with DKA due to T1DM were treated as inpatients at Can Tho Children's Hospital from 2021-2024. Results: The risk of severe DKA in children under 5 years old was 1.5 higher than in children aged 5 years and older (95% CI: 0.13-16.54); women were 3 higher than men (95% CI: 0.63-14.12); Children living in rural areas were 2.46 higher than children living in urban areas (95% CI: 0.41-14.63); misdiagnosis was 2.81 higher than the correct initial diagnosis group (95% CI: 0.28-27.97). The average time to resolve acidosis was 24.08 hours, with a statistically significant difference between DKA severity groups (p<0.05). DKA complications were including acute kidney injury (80.6%), hypokalemia (80.6%), hypoglycemia (58.1%), cerebral edema (6.5%), and no patient deaths. Conclusions: Young children, female gender, difficult medical access (rural location) misdiagnosis, and delayed treatment were risk factors that increase the risk of severe DKA. Hypoglycemia, hypokalemia, and acute kidney injury were common complications in DKA. 

Article Details

Keywords

Type 1 diabetes mellitus, T1DM, DKA

References

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