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Date Published: 02/08/2024
Online Published: 02/08/2024
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DOI: https://doi.org/10.58490/ctump.2024i77.2609
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No. 77 (2024): HỘI NGHỊ THƯỜNG NIÊN HỌC VIÊN – SINH VIÊN NGHIÊN CỨU KHOA HỌC LẦN THỨ IV NĂM 2024
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Nguyen, T. H. D., Huynh, T. H., & Ngo, H. L. (2024). IMAGING FEATURES AND PAIN SCORES CHANGES FOLLOWING BISPHOSPHONATE TREATMENT IN EARLY-STAGE KNEE OSTEOARTHRITIS PATIENTS WITH REDUCED BONE DENSITY AT CAN THO CENTRAL GENERAL HOSPITAL. Cantho Journal of Medicine and Pharmacy, 77, 1-7. https://doi.org/10.58490/ctump.2024i77.2609

IMAGING FEATURES AND PAIN SCORES CHANGES FOLLOWING BISPHOSPHONATE TREATMENT IN EARLY-STAGE KNEE OSTEOARTHRITIS PATIENTS WITH REDUCED BONE DENSITY AT CAN THO CENTRAL GENERAL HOSPITAL

Thi Hong Diem Nguyen1,, Thanh Hien Huynh2, Hoang Long Ngo2
1 Can Tho Central General Hospital
2 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Bisphosphonates, known for their bone resorption inhibition properties, are frequently utilized in osteoporosis management. Recent studies have shown promising outcomes regarding bisphosphonates as a therapeutic option for early-stage knee osteoarthritis (OA). Objective: To evaluate changes in pain scores and imaging findings following Bisphosphonate therapy in patients with early-stage knee OA and reduced bone density. Materials and methods: A prospective observational study analyzing cross-sectional data of 37 patients with early-stage knee OA and reduced bone density treated with Bisphosphonates from March 2023 to September 2023. Results: Among 37 patients (66 knee joints) with a mean age of 69.0 ± 8.4, 97.3% were female. 15/37 patients (40.5%) had osteoporosis, while the remainder had osteopenia. After six months of treatment, there was a significant improvement in VAS scores (2.2 ± 0.5 vs. 4.5 ± 1.1, p<0.001) and WOMAC scores (26.3 ± 11.7 vs. 47.4 ± 21.3, p<0.001). X-ray imaging showed a reduction in knee OA stage in 6/48 knee joints (12.5%). Ultrasound revealed improved synovial fluid thickness and synovial membrane, but not statistically significant. Knee osteophyte formation decreased significantly after six months of treatment (p=0.017), while cartilage remained stable. Conclusion: Bisphosphonates demonstrate pain reduction, improved knee function, and reduced degenerative progression on imaging and ultrasound, proving to be effective in treating early-stage knee osteoarthritis with minimal adverse effects.

Article Details

Keywords

bisphosphonates, knee osteoarthritis, early-stage, reduced bone density, VAS score, WOMAC score

References

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