Article Sidebar
Views PDF: 344
EVALUATION OF ANTIOXIDANT ACTIVITY OF SALAZINIC ACID FROM THE LICH EXTRACT Parmotrema tinctorum
Main Article Content
Abstract
Background: Salazinic acid is a depsidone containing a lactone ring, found in some lichen species and commonly in the genus Parmotrema. Salazinic acid possesses many attractive biological activities such as antibacterial, antifungal, anticancer and blood sugar control activities... Studies have evaluated the antioxidant activity of this acid is still very limited, especially in Vietnam. Objectives: To Evaluate of antioxidant activity of salazinic acid isolated from lichen growing in Vietnam. Materials and methods: Salazinic acid isolated from acetone extract of the lichen Parmotrema tinctorum. Antioxidant activity was evaluated by DPPH free radical scavenging method, ABTS●+ free radical scavenging method, reducing power method (RP), and total antioxidant capacity method (TAC). Results: Salazinic acid shows antioxidant ability when investigated by DPPH, ABTS, RP and TAC methods with IC50 or OD0.5 values respectively IC50 2381.53 ± 22.13 μg/mL, IC50 3154, 99 ± 87.47 μg/mL, OD0.5 1572.11 ± 17.17 μg/mL, OD0.5 1499.50 ± 35.76 μg/mL. Conclusion: Salazinic acid shows its antioxidant potential using many different evaluation methods, promising to be an effective source of antioxidants for further applied research.
Article Details
Keywords
Lichen, salazinic acid, antioxidant
References
2. Manojlović, Nedeljko, et al. Chemical composition of three Parmelia lichens and antioxidant, antimicrobial and cytotoxic activities of some their major metabolites. Phytomedicine 19.13 2012. 19(13), 1166-1172, doi: 10.1016/j.phymed.2012.07.012.
3. De Paz, G. Amo, et al. HPLC isolation of antioxidant constituents from Xanthoparmelia spp. Journal of Pharmaceutical and Biomedical Analysis. 2010. 53(2), 165-171, doi: 10.1016/j.jpba.2010.04.013.
4. Nguyen, Tram Thi Thu, et al. Photoprotective activity of lichen extracts and isolated compounds in Parmotrema tinctorum. Biointerface Research in Applied Chemistry. 2021. 11(5), 1265312661, doi:10.33263/BRIAC115.1265312661.
5. Sharma, Om P., and Tej K. Bhat. DPPH antioxidant assay revisited. Food chemistry . 2009. 1202-1205, doi: 10.1016/j.foodchem.2008.08.008.
6. Nenadis, Nikolaos, et al. Estimation of scavenging activity of phenolic compounds using the ABTS•+ assay. Journal of agricultural and food chesmistry. 2004. 52(15), 4669-4674. doi:10.1021/jf0400056.
7. Ferreira, Isabel CFR, et al. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity. Food chemistry. 2007. 100(4), 1511-1516, doi: 10.1016/j.foodchem.2005.11.043.
8. Prieto, Pilar, Manuel Pineda, and Miguel Aguilar. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Analytical biochemistry. 1999. 269(2), 337-341, doi: 10.1006/abio.1999.4019.
9. Kumar, Tatapudi Kiran, et al. Salazinic Acid and Norlobaridone from the Lichen Hypotrachyna cirrhata: Antioxidant Activity, α-Glucosidase Inhibitory and Molecular Docking Studies. Molecules. 2023. 28(23), 7840, doi: 10.3390/molecules28237840.
10. Selvaraj, G., A. Tinabaye, and R. Ananthi. In vitro antioxidant activities of Salazinic acid and its derivative hexaacetylsalazinic acid. International Journal of Research in Engineering and Technology. 2015, 4(2), 345-355.
11. Killari, Kishore Naidu, et al. Salazinic acid attenuates male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic albino rats. RSC advances. 2023. 13(19), 12991-13005, doi: 10.1039/D3RA01542D.
12. Manojlović, Nedeljko, et al. Chemical composition of three Parmelia lichens and antioxidant, antimicrobial and cytotoxic activities of some their major metabolites. Phytomedicine. 2012. 19(13), 1166-1172, doi: 10.1016/j.phymed.2012.07.012.