ĐỊNH HƯỚNG TÁC NHÂN VI SINH VẬT GÂY TIÊU CHẢY CẤP TRẺ EM: VAI TRÒ CỦA BẠCH CẦU MÁU VÀ C-REACTIVE PROTEIN

Abstract

Background: White blood cells and C-reactive protein are biomarkers that reflect inflammation. Targeting agents causing acute diarrhea in children based on biomarkers is expected. Objectives: To determine the value of blood white blood cells, CRP, and the rate of the microbes causing acute diarrhea in children under 5 years old; to determine the relationship between white blood cells, C-reactive protein and the microbial agents. Materials and method: A cross-sectional description study was conducted on 74 children under 5 years old diagnosed with acute diarrhea at the Gastroenterology Department of Can Tho Children's Hospital from December 2022 to August 2023. Results: Virus was the main agent (41.9%), followed by bacterial-virus co-infection (21.62%), bacterial infection (18.91%), and other microbial infections (4%). The four main agents detected by Real-time polymerase chain reaction were Rotavirus group A (41.9%), Shiga toxin-producing Escherichia coli, Enterotoxigenic Escherichia coli, and Salmonella. Increased white blood cells rate accounted for 32.4%, and increased C-reactive protein rate accounted for 59.5%. There was no correlation between C-reactive protein values and blood white blood cells with groups of viral or bacterial agents causing acute diarrhea (p>0.05). Conclusion: Virus is the main agent causing acute diarrhea in children under 5 years old. White blood cells and C-reactive protein do not play a role in targeting the microbes.  Therefore, microbiological diagnosis based on white blood cells and C-reactive protein in this subject should be carefully considered.