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Date Published: 06/11/2023
Online Published: 06/11/2023
Abstract Views: 151
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DOI: https://doi.org/10.58490/ctump.2023i67.2175
Issue
No. 67 (2023)
Section
Article
How to Cite
Thai, T. H. N., Nguyen, T. H., Nguyen, H. P., Nguyen, T. H. Y., Nguyen, T. B. H., Nguyen, T. M. N., & Ha, T. M. T. (2023). THE PREVALENCE OF THE CAGA GENE OF HELICOBACTER PYLORI AND ITS ASSOCIATION WITH GASTRODUODENAL DISEASES. Cantho Journal of Medicine and Pharmacy, 67, 13-19. https://doi.org/10.58490/ctump.2023i67.2175

THE PREVALENCE OF THE CAGA GENE OF HELICOBACTER PYLORI AND ITS ASSOCIATION WITH GASTRODUODENAL DISEASES

Thi Hong Nhung Thai1,2,, Thai Hoa Nguyen1, Hong Phong Nguyen1, Thi Hai Yen Nguyen1, Thi Be Hai Nguyen1, Thi Mai Ngan Nguyen2, Thi Minh Thi Ha2
1 Can Tho University of Medicine and Pharmacy
2 University of Medicine and Pharmacy, Hue University

Main Article Content

Abstract

Background: Helicobacter pylori is the leading cause of gastroduodenal diseases. The CagA protein, which is encoded by the cagA gene, is the well-studied toxin of H. pylori. Objectives: (1) To determine the prevalence of the cagA gene of H. pylori isolates from patients with gastroduodenal diseases, (2) to investigate the association between the cagA gene and gastroduodenal diseases.  Materials and methods: The study was conducted on 173 positive – H. pylori patients with gastroduodenal disease. H. pylori strains were isolated from gastric mucosa biopsy specimens. The polymerase chain reaction technique was performed to identify the cagA gene. Results: The cagA gene was detected in 83.8% of H. pylori isolates. After adjusting for age and gender, the multivariable logistic regression analysis showed that the H. pylori strain carrying cagA-positive gene was associated with an increased risk for peptic ulcers (aOR = 5.49, 95% CI: 1.06-28.37, p = 0.042). Conclusion: The percentage of H. pylori strains carrying the cagA gene is great. The cagA gene was related to an increased risk for peptic ulcers.

Article Details

Keywords

Helicobacter pylori, cagA gene, gastroduodenal diseases

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