GIÁ TRỊ XÉT NGHIỆM CA125, HE4 VÀ ROMA TEST TRONG CHẨN ĐOÁN UNG THƯ BUỒNG TRỨNG TẠI BỆNH VIỆN QUỐC TẾ PHƯƠNG CHÂU

Abstract

Background: Ovarian cancer is the second most common gynecological cancer in women, is one of the deadliest cancers, leading cause of death in women. Objectives: To determine the value of two tests CA125, HE4 and ROMA test index (Risk of Ovarian Malignancy Algorithm Test) in ovarian cancer diagnosis at Phuong Chau International Hospital. Materials and methods: A crosssectional descriptive study on 244 women diagnosed with organic ovarian tumors from 03/2019 to 09/2023 at Phuong Chau International Hospital. Results: CA125 test has sensitivity of 61.5%, specificity of 67.1%, positive predictive value of 9.5%, negative predictive value of 96.9%. The HE4 test has a sensitivity of 53.8%, a specificity of 97.8%, a positive predictive value of 58.3%, and a negative predictive value of 97.4%. The ROMA test index has a sensitivity of 53.8%, specificity of 93.1%, positive predictive value of 30.4%, negative predictive value of 97.3%. Conclusions: Among the two tests CA125, HE4 and ROMA test index, the HE4 test has the most optimal value, so it can be a substitute for cases that are not eligible to perform combined tests in differential diagnosis of cancer. Ovarian cancer in women diagnosed with organic ovarian tumors. Keywords: Ovarian cancer, CA125, HE4, ROMA test.