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Date Published: 31/08/2023
Online Published: 31/07/2023
Abstract Views: 148
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DOI: https://doi.org/10.58490/ctump.2023i62.2079
Issue
No. 62 (2023)
Section
Article
How to Cite
Tran, Q. D., Huynh, C. T., Nguyen, M. H., & Huynh, L. T. V. (2023). EVALUATING EFFICACITY OF LOW-DOSED KETAMINE AND MIDAZOLAM IN LAPAROTOMY HYSTERECTOMY AND ABDOMINAL MYOMECTOMY AT CAN THO GYNECOLOGY AND OBSTETRICS HOSPITAL IN 2022. Cantho Journal of Medicine and Pharmacy, 62, 243-249. https://doi.org/10.58490/ctump.2023i62.2079

EVALUATING EFFICACITY OF LOW-DOSED KETAMINE AND MIDAZOLAM IN LAPAROTOMY HYSTERECTOMY AND ABDOMINAL MYOMECTOMY AT CAN THO GYNECOLOGY AND OBSTETRICS HOSPITAL IN 2022

Quoc Duy Tran1,, Cong Tam Huynh1, Minh Hoang Nguyen1, Le Thien Vu Huynh1
1 Can Tho Gynecology and Obstetrics Hospital

Main Article Content

Abstract

Background: Ketamine has been shown to a postoperative analgesic effect. Nevertheless, whether this effect still exists after being combined with combined spinal use bupivacaine – opiphine of billion cutting offer and optional disclaimer of fibroids remains unclear. Objectives: To evaluate results of combined analgesia in laparotomy hysterectomy and abdominal myomectomy of ketamine plus low-dose midazolam at skin incision. Materials and methods: Study on clinical trial of 116 patients with indications for laparotomy hysterectomy and abdominal myomectomy with spinal anesthesia and postoperative pain relief with spinal opiate Opiphine, divided into 2 groups: ketamine group (ketamine 1mg/kg and midazolam 1mg), control group (using sodium chloride 0.9% 5ml) before skin incision; monitoring: effectiveness of analgesia in surgery (good, moderate, failed), rescue pain relief and rescue analgesic dose (when VAS > 4), monitoring for unwanted effects. Results: The ketamine group and control group, achieved the following results: the effectiveness of ketamine/control group in pain relief was no different. The difference between the 2 groups (CI: 0.69-5.32, p>0.05), patients using rescue pain relief in the ketamine group was lower than the control group (25.9% compare to 50%; p < 0 .05; CI: 0.16-0.76), pain index VAS at rest at the time of T1, T2 and T5 was not statistically significant (p>0.05), pain index at The time T3, T4 in the ketamine group was statistically significant (p < 0.05). No patient experienced hallucinations, nightmares, double vision, or excessive sedation with low doses of ketamine. Conclusions: Intravenous low-dose ketamine when combined with spinal anesthesia with bupivacaine and postoperative analgesia with opiphine has an effective analgesia effect after surgery, side effects were not significant.

Article Details

Keywords

Low-dosed ketamine, postoperative acute pain, gynecological

References

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