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Date Published: 25/12/2023
Online Published: 25/12/2023
Abstract Views: 96
Views PDF: 112
DOI: https://doi.org/10.58490/ctump.2023i69.1783
Issue
No. 69 (2023)
Section
Article
How to Cite
Le , N. T., Le , B. N., Tran, L. Q. N., Tran, T. C., Dang , D. K., Nguyen , N. N. T., Tran, D. T., & Duong , X. C. (2023). RESEARCH ON THE HEPATOPROTECTIVE FUNCTIONS OF PYCNOPORUS SANGUINEUS EXTRACT. Cantho Journal of Medicine and Pharmacy, 69, 177-184. https://doi.org/10.58490/ctump.2023i69.1783

RESEARCH ON THE HEPATOPROTECTIVE FUNCTIONS OF PYCNOPORUS SANGUINEUS EXTRACT

Nhut Truong Le 1,, Bao Ngan Le 1, Le Quynh Nhu Tran1, Tham Co Tran1, Duy Khanh Dang 1, Ngoc Nha Thao Nguyen 1, Duc Tuong Tran2, Xuan Chu Duong 1
1 Can Tho University of Medicine and Pharmacy
2 Dong Thap University

Main Article Content

Abstract

Background: Hepatitis is a common disease not only in Vietnam but also worldwide. This condition can lead to dangerous complications such as liver fibrosis, cirrhosis, liver cancer, and even death. Pycnoporus sanguineus has long been recognized as a valuable medicinal herb, numerous studies have been conducted on the biological and chemical properties of Pycnoporus sanguineus, particularly its anti-inflammatory, anti-cancer, antioxidant,... There have been a few specific studies on its hepatoprotective effects in Vietnam. Objectives: To investigate of the therapeutic effects of Pycnoporus sanguineus extract in supporting the treatment of liver injury by carbon tetrachloride (CCl4) in mice model. Materials and Methods: The material is extract from Pycnoporus sanguineus (MH225776). The model will be created using Swiss albino mice, inducing liver toxicity with carbon tetrachloride (CCl4), and using the extract to investigate its therapeutic effects. Results: The results showed that after 7 days of toxicity and giving the extract for 14 days at the same time, the level of enzymes ALT, AST, and MDA decreased compared to the control group. The analysis of mouse liver histology and morphology showed that the ethanol extract of Pycnoporus sanguineus mushroom had a significant effect in reducing liver inflammation compared to the control group. Conclusion: The Pycnoporus sanguineus extract exhibits the effect on supporting the treatment of liver diseases.

Article Details

Keywords

Pycnoporus sanguineus, hepatoprotective, carbon tetrachloride, mushroom extract

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