NGHIÊN CỨU TÁC DỤNG HẠ ĐƯỜNG HUYẾT CỦA CAO CHIẾT HÀNH TÍM (ALLIUM ASCALONICUM L., ALLIACEAE) TRÊN MÔ HÌNH CHUỘT GÂY TĂNG ĐƯỜNG HUYẾT BẰNG ALLOXAN

Abstract

Background: Currently, the incidence of diabetes has been rapidly increasing all over the world, especially diabetes has become more and more common in the young age group. The longterm use of drugs causes side effects for patients, so natural compounds capable of improving blood sugar levels have been paid attraction to by researchers recently. Shallot has been shown to inhibit α-glucosidase and is one of the most potent medicinal ingredients in treating diabetes. Objectives: The hypoglycemic effect of Allium ascalonicum extract was studied in a model by inducing hyperglycemia in mice with alloxan. Materials and methods: Shallot extract with 10% moisture content. Alloxan was injected into the white mice’s peritoneum at a dose of 150mg/kg; after 72 hours, the mice’s tail vein blood was collected to check fasting blood sugar; mice with blood glucose greater than or equal to 200mg/dL were selected for the next steps; mice successfully caused hyperglycemia were divided into 4 different groups: A negative control group got distilled water, a positive control group treated with a metformin dose of 250mg/kg, one group treated with red onion extract at a dose of 500mg/kg, and the remaining one treated with red onion extract at a dose of 1000mg/kg; the biological control group had normal physiological blood glucose levels. Their blood glucose levels and weight were monitored and recorded every week. Results: The model used to induce hyperglycemia in white mice had a success rate of 70%; the blood glucose concentration in both treatment groups decreased significantly (p<0.05) compared with the negative control group; the effects of shallot extract in two of these groups were similar to that of metformin in the positive control group. Conclusions: The model used to induce hyperglycemia with alloxan in white mice was successfully conducted; the research also showed that shallot extract at doses of 500mg/kg and 1000mg/kg had hypoglycemic effects.