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Date Published: 12/06/2023
Online Published: 12/06/2023
Abstract Views: 190
Views PDF: 438
Issue
No. 29 (2020)
Section
Article
How to Cite
Huynh, C. T., Le , V. L., Nguyen , P. T., Le , Q. V., & Nguyen , H. T. (2023). THE EFFECTIVENESS OF ONDANSETRON AND EXAMETHASONE COMBINATION IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING LAPAROSCOPIC CHOLESCYSTECTOMY AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL. Cantho Journal of Medicine and Pharmacy, 29, 14-20. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/1577

THE EFFECTIVENESS OF ONDANSETRON AND EXAMETHASONE COMBINATION IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING LAPAROSCOPIC CHOLESCYSTECTOMY AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Chien Thang Huynh1,, Vu Linh Le 1, Phuong Thanh Nguyen 1, Quoc Vinh Le 1, Huu Thong Nguyen 1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Postoperative nausea and vomiting (PONV) are a most common and distressing symptoms within the first 24 hours post-operatively, especially on biliary surgery. Therefore, management of PONV for patients is essential to the best recovery outcome for patients. Objectives: To evaluate the efficacy of combination of dexamethasone and ondansetron for postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Materials and methods: A prospective, cross sectional study was conducted with 64 patients who undergoing laparoscopic cholescystectomy with general anesthesia and IV 4 mg dexamethasone after induction, IV 8 mg ondansetron at ending of surgery. The incidence, severity and complication of PONV were observed within 06 hours postoperatively. Results: The incidence of PONV within 0–06 hours postoperatively was 14.9%. Rescue antiemetics was required in 1 patient (1.5%). In our study, the most frequently reported adverse effects were 9.0% shivering, 16.4% dizziness, 1.5% headache and 1.5% transient dyspnea. Conclusion: The incidence of complete response within 06 hours postoperatively is 85.1%.

Article Details

Keywords

Postoperative nausea and vomiting, dexamethason, ondansetron

References

1. Nguyễn Văn Chừng, Nguyễn Thị Ánh Hiền (2011), "Nghiên cứu hiệu quả dự phòng buồn nôn – nôn của ondansetron phối hợp dexamethason sau phẫu thuật tai mũi họng", tạp chí Y học TP Hồ Chí Minh, 15 (1), tr 340-344.
2. Nguyễn Thanh Tú, Nguyễn Hữu Tú (2014), Các yếu tố liên quan đến tình trạng nôn và buồn nôn của bệnh nhân sau mổ, Tạp chí nghiên cứu Y học, 87 (2), tr 74-82.
3. Ahsan K, and et al. (2014), Comparison of efficacy of ondansetron and dexamethasone combination and ondansetron alone in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy, J Pak Med Assoc, 64 (3), pp 242-246.
4. Alia I, and et al. (2015), Comparison of ondansetron and combination of ondansetron and dexamethasone for prevention of post-operative nausea and vomiting in patients undergoing elective laparoscopic cholecystectomy, Pakistan Journal of Medical and Health Sciences, 9 (4), pp 1387-1389.
5. Bhattarai B, Shrestha S, Singh J (2011), Comparison of ondansetron and combination of ondansetron and dexamethasone as a prophylaxis for postoperative nausea and vomiting in adults undergoing elective laparoscopic surgery, J Emerg Trauma Shock, 4 (2), pp 168-172.
6. Elhakim M, Nafie M, Mahmoud K, Atef A (2002), Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy, Can J Anaesth, 49 (9), pp 922-926.
7. Murphy GS, Szokol J W, and et al. (2011), Preoperative Dexamethasone Enhances Quality of Recovery after Laparoscopic Cholecystectomy: Effect on In-hospital and Postdischarge Recovery Outcomes, Anesthesiology: The Journal of the American Society of Anesthesiologists, 114 (4), pp 882-890.
8. Fujii Y, Itakura M (2010), RETRACTED ARTICLE: Reduction of postoperative nausea, vomiting, and analgesic requirement with dexamethasone for patients undergoing laparoscopic cholecystectomy, Surgical Endoscopy, 24 (3), pp 692-696.
9. Gan TJ, and et al. (2020), Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting, Anesth Analg, 131 (2), pp 411-448.
10. Gautam B, and et al. (2008), Antiemetic prophylaxis against postoperative nausea and vomiting with ondansetron-dexamethasone combination compared to ondansetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy, Kathmandu Univ Med J (KUMJ), 6 (23), pp 319-328.
11. Koivuranta M, Laara E, Snare L, Alahuhta S (1997), A survey of postoperative nausea and vomiting, Anaesthesia, 52 (5), pp 443-449.
12. Rajnikant Kumar, Bhukal I, Kaloria N, Soni S L, and et al. (2019), Comparison of Palonosetron and Dexamethasone with Ondansetron and Dexamethasone to Prevent Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy, Anesthesia, essays and researches, 13 (2), pp 317-322.