CLINICAL AND SUBCLINICAL CHARACTERISTICS AND RISK FACTORS FOR RELAPSE IN PATIENTS WITH NEPHROTIC SYNDROME AT CAN THO CHILDREN HOSPITAL
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Abstract
Background: Nephrotic syndrome (NS) is a less frequent disease in children but often relapse after prednisolone treatment. The purpose of this study was to describe clinical and paraclinical characteristics and identify risk factors for relapse in children with NS. Materials and methods: A cohort study of 70 pediatric patients at Can Tho Children Hospital from January 1st, 2019 to June 30th, 2020. Using univariate and multivariate proportional hazard analysis to identify the risk factors for relapse in patients with NS. Results: A total of 70 patients with NS were admitted to the hospital, the median age was 7.0 (4.7-11) years old, male gender accounted for 71.4% (50/70). The median follow-up time was 7.2 (2.2-11.8) months. Relapses were occurred in 20 patients (28.5%). There were 4 independent risk factors for relapses: age group ≤ 5 (Hazard ratio (HR) and 95% confidence interval (CI), 4.31 (1.28-14.52); proteinuria/24 hours > 3g / L, HR = 5.69 (95% CI: 1.41-22.83); Blood cholesterol> 10.6 mmol / L, HR = 3.89 (95% CI 1.15 -13.13) and blood creatinine > 91 µmol / L, HR = 102.6 (95% CI: 5.04-2089). Conclusion: A high serum level of cholesterol and creatinine, a high level of proteinuria and young age at onset increased the relapse rate in children with nephrotic syndrome
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Keywords
Nephrotic syndrome, relapse, proteinuria
References
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