KHẢO SÁT CÔNG DỤNG ĐIỀU TRỊ TIÊU CHẢY DO KHÁNG SINH CỦA MỘT SỐ CHẾ PHẨM CHỨA PROBIOTIC TRÊN THỊ TRƯỜNG

Abstract

Background: The using of probiotic praducts is more and more popular. Many researches of security and effect of probiotic have been done and published already. However, there are many ideas that the quality and effect of these products are not guaranteed. Objectives: The objective of this paper is analyzing the quality and surveying the effect on diarrhea due to antibiotics on white rat model of some probiotic products circulating on market.  Materials and methods: Some products containing probiotic strains on market was analyzed including isolation by streak plate method; qualification with Gram staining (modified Hucker method), acid-fast staining (Ziehl - Neelsen method), endospore staining (Schaeffer - Fulton method) and some biochemical reactions; quantification by pour plate technique and detection of pathogenic microorganisms. Some products which qualified about qualification and quantification were chosen for surveying effect on diarrhea due to antibiotics with model of diarrhetic rats due to combination of streptomycin and lincomycin. Results: There are 5 out of 23 products had composition and amount of probiotic strains as declaration on the label. Surveying the effect on diarrhea relating to antibiotics of these 5 products, the result showed that testing groups had the lower dead rate and higher treated rate than positive reference group, the level of weight increase of testing group was higher than positive reference group with statistically difference (p <0.05). Conclusions: 18/23 products did not have quantification and/or qualification as declaration 5 qualified products about qualification and quantification had the ability of treating diarrhea due to antibiotics on model of rat.