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Date Published: 21/06/2023
Online Published: 21/06/2023
Abstract Views: 259
Views PDF: 301
Issue
No. 30 (2020)
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Article
How to Cite
Duong, T. P., Le , N. C., Lam, V. N., Do, V. M., & Mai, T. T. T. (2023). ANTIMICROBIAL RESISTANT STATUS OF KLEBSIELLA PNEUMONIAE AT CAN THO CENTRAL GENERAL HOSPITAL IN 2019. Cantho Journal of Medicine and Pharmacy, 30, 115-121. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/1549

ANTIMICROBIAL RESISTANT STATUS OF KLEBSIELLA PNEUMONIAE AT CAN THO CENTRAL GENERAL HOSPITAL IN 2019

Truong Phu Duong1,, Ngoc Cua Le 2, Vinh Nien Lam3, Van Mai Do1, Thi Thanh Thuong Mai4
1 Tay Do University
2 Walailak University – Thailand
3 University of Medicine and Pharmacy at Ho Chi Minh City
4 Can Tho Medical College

Main Article Content

Abstract

Background: Klebsiella pneumoniae is an important causative agent of hospital-acquired infections, including severe pneumonia, urinary tract infection as well as septicemia and wound infections. Objective: Analyzing the antibiotic resistance of Klebsiella pneumoniae at Can Tho Central General Hospital in 2019. Materials and methods: 256 medical records at ICU and Infectious Respiratory Department with Klebsiella pneumoniae infection according to CLSI guidelines. Results: Antibiogram results show that antibiotics of Beta - lactam group had a high rate of resistance, specifically: cephalosporine family: cefazolin (83.8%), ceftriaxone (80.2%), ceftazidime (80.4%), cefepime (78.1%). Penicillin family: moderate spectrum: ampicillin (99.2%), amoxicillin/clavulanic acid (76.4%), ampicillin/sulbactam (83.8%), piperacillin (87.5%), broad spectrum: ticarcillin (100%), ticarcillin / clavulanic acid (50.0%) piperacillin/tazobactam (66.3%). Monobactam family: aztreonam (100%). Some other groups of antibiotics also had high resistance such as fluoroquinolone and nitrofurantoin group with resistance level > 70%. Among the carbapenems, imipenem had the highest rate of resistance at 54.5%. Conclusion: Antibiotic indications must be based on microbiological evidence in order to improve the effectiveness of resistance reduction. 

Article Details

Keywords

Antibiogram, Klebsiella pneumoniae, antibiotic resistance

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