ĐẶC ĐIỂM LÂM SÀNG, HÌNH ẢNH NỘI SOI, VÀ SO SÁNH KẾT QUẢ ĐIỀU TRỊ CÁC THUỐC ESOMEPRAZOL 40MG HOẶC PANTOPRAZOL 40MG Ở BỆNH NHÂN TRÀO NGƯỢC DẠ DÀY THỰC QUẢN TẠI TRUNG TÂM Y TẾ HUYỆN GIỒNG RIỀNG TỈNH KIÊN GIANG NĂM 2022-2023

Abstract

Background: Gastroesophageal reflux disease is the most common gastrointestinal disease worldwide and a high contributing cause affecting quality of life. Objectives: 1) To describe clinical features, endoscopic images of Gastroesophageal; 2) To compare the treatment results of patients with gastroesophageal reflux disease by Esomeprazole 40mg or Pantoprazole 40mg. Material and methods: A prospective study with therapeutic intervention was conducted on 80 outpatients with gastroesophageal reflux disease. Results: There was 51.0% female, average age 50.8 ± 15.1. Kinh people accounted for 93.75%, manual workers accounted for 83.75%. Symptoms: Heartburn (60.0%), vomiting (82.5%), abdominal pain (81.25%), nausea (46.25%), difficulty swallowing (30%), non-cardiac chest pain 28,75%, persistent cough 25,0%, hoarseness 5,0% . Injury to the esophagus through endoscopy: LA-A (97.5%), LA-B (2.5%). Treatment results: The symptoms of burning behind the sternum and spitting up in the esomeprazole group were 10.0% and 12.5%, respectively, and the pantoprazol group was 17.5% and 22.5, respectively, with p=0.052. The mean GERDQ score in the esomeprazole group was 5.525 ± 1.01 and in the pantoprazole group was 6.0 ± 1.01 with p=0.252. Esophageal healing rate in the esomeprazole group accounted for 87.5%, the pantoprazol group was 80.0%, with p=0.370. Conclusion: The successful rate of GERD treatment in the esomeprazole 40mg group was 87.5%, the pantoprazole 40mg group was 80.0%, the difference between the two groups was not statistically significant.