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Date Published: 30/09/2023
Online Published: 30/09/2023
Abstract Views: 461
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DOI: https://doi.org/10.58490/ctump.2023i64.1259
Issue
No. 64 (2023)
Section
Article
How to Cite
Tran, T. H. N., Pham, T. S., Nguyen, P. N., & Tran, Q. T. (2023). THE SITUATION OF ANTIBIOTIC DOSAGE ADJUSTMENT IN PATIENTS WITH RENAL FAILURE AT LONG AN GENERAL HOSPITAL IN 2022-2023. Cantho Journal of Medicine and Pharmacy, 64, 1-8. https://doi.org/10.58490/ctump.2023i64.1259

THE SITUATION OF ANTIBIOTIC DOSAGE ADJUSTMENT IN PATIENTS WITH RENAL FAILURE AT LONG AN GENERAL HOSPITAL IN 2022-2023

Thi Hong Nga Tran1,, Thanh Soul Pham2, Phuong Nam Nguyen1, Quoc Truong Tran2
1 Long An General Hospital
2 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Infectious diseases occur in 60-80% of patients with renal failure, and dose adjustment of antibiotics is important and necessary to ensure efficacy and minimize the risk of drug toxicity, optimize treatment and treatment costs. Objectives: 1. To determine the characteristics of antibiotic use in patients with renal failure. 2. To determine the dose adjustment rate and some factors related to the unreasonable adjustment of antibiotic doses in patients with renal impairment. Materials and methods: A cross-sectional study conducted among 256 medical records with antibiotic indications in patients with renal impairment and 28 doctors at the Department of Renal Pulmonary - Long An General Hospital in 2022-2023. Results: The β-lactam group had the highest number of prescriptions, accounting for (66.4%). Next is the fluoroquinolone group (24.2%). Amoxicillin + clavulanic acid had the highest number of prescriptions, accounting for (18.2%) and the lowest was clarithromycin 0.3%. The proportion of medical records of patients adjusting for inappropriate antibiotic doses generally accounted for 19.1%. Factors related to the inappropriate dose adjustments of antibiotic with glomerular filtration rate in patients (p=0.001). Factors related to the inappropriate dose adjustments of antibiotic with professional qualifications of doctors (p=0.001). Conclusion: The proportion of medical records adjusted for inappropriate antibiotic doses accounts for a high proportion. The results of the study suggest that it is necessary to monitor and advise Medical staff about renal dosage adjustments.

Article Details

Keywords

Renal impairment, Glomerular filtration rate, antibiotic, dose adjustment

References

1. Chahine B. Antibiotic dosing adjustments in hospitalized patients with chronic kidney disease: a retrospective chart review. Int Urol Nephrol. 2022. 54(1),157-163. doi: 10.1007/s11255-021-02834-6.
2. Lưu Quang Huy. Phân tích việc hiệu chỉnh liều kháng sinh cho bệnh nhân suy thận tại bệnh viện Bạch Mai, Luận văn Thạc sĩ Dược học, Trường Đại học Dược Hà Nội. 2018.
3. David N.G, Henry F.C., Michael S.S. The Sanford Guide to Antimicrobial Therapy, 52nd Edition, Antimicrobial Therapy, Inc. 2022.
4. Bộ Y tế. Dược thư quốc gia Việt Nam. NXB Y học. 2022.
5. Fahimi F., Emami S., Farokhi F. R. The rate of antibiotic dosage adjustment in renal dysfunction. Iran J Pharm Res. 2019. 11 (1), 157-161.
6. Saad R, Hallit S, Chahine B. Evaluation of renal drug dosing adjustment in chronic kidney disease patients at two university hospitals in Lebanon. Pharm Pract (Granada). 2019. 17 (1), 1304.
7. Onyango M. A. et al. Determinants of appropriate antibiotic dosing in patients with chronic kidney disease in a Kenyan referral hospital. Afr J Pharmacol Ther. 2018. 3 (1), 19-28.
8. Đào Thị Mai Anh. Khảo sát hiệu quả chỉnh liều kháng sinh trên bệnh nhân bệnh thận mạn đang lọc máu tại bệnh viện Thống Nhất. Luận văn thạc sĩ dược học. Trường Đại học Dược Hà Nội. 2017.
9. Triệu Thị Tuyết Vân. Khảo sát tình hình hình sử dụng kháng sinh trên bệnh nhân suy thận mạn tính tại khoa thận tiết niệu bệnh viện Bạch Mai. Tạp chí Y Dược học lâm sàng 108. 2019.