NGHIÊN CỨU BÀO CHẾ VIÊN NANG HỖ TRỢ GIẢM CÂN CHIẾT XUẤT TỪ LÁ DÂU TẰM, LÁ SEN, LÁ TRÀ XANH VÀ QUẢ MƯỚP ĐẮNG

Abstract

Background: The trend favoring going back to nature and substituting medical herbs for artificial chemicals is slowly gaining popularity. Numerous solitary investigations revealed that medicinal plants like mulberry, lotus leaf, green tea, and bitter melon fruit have impacts on weight loss. It is crucial to combine medicinal herbs to increase the effect, especially because these are allnatural items. Purpose: To conduct research, create a weight-loss supplement including bitter melon fruit, lotus leaves, green tea leaves, and extracts from mulberry leaves. Objectives: To conduct research, produce, and test product standards for a weight-loss capsule including extracts from mulberry, lotus, green tea, and bitter melon fruit. Material and Methods: Mulberry leaf extract, lotus leaf extract, green tea leaf extract, and bitter gourd fruit extract were the research subjects. Examine the ratios of adhesive and filler excipients and assess the formulation choice using a flow rate of 2–6 s/100 g, a humidity of 2–4%, and an apparent density of 0.64–0.67 g/mL. Check the final items for compliance with Vietnam Pharmacopoeia V's requirements for capsules. Results: Capsule formula contains 15% dried mulberry leaf extract, 31% dried lotus leaf extract, 12.5% dried green tea leaf extract, 9% dried bitter gourd fruit extract, 15% lactose, 2% arabic gum, 1% magiesium stearate, and magiesium carbonate, making a total formula of 100% that meets testing standards including weight uniformity, disintegration under 30 minutes, qualitative and quantitative determination, and total polyphenol content reaching 47.3552 mg GAE/g granules. Conclusion: Successfully prepared and evaluated the test criteria for capsules containing extracts from mulberry leaves, lotus leaves, green tea leaves, and bitter melon fruit to help support weight loss.