BÀO CHẾ VI NANG DICLOFENAC NATRI TAN TRONG RUỘT BẰNG PHƯƠNG PHÁP SẤY PHUN

Abstract

  Background: microcapsulation technique not only helps to hide unpleasant taste, avoid incompatibility, increase stability and solubility of the pharmaceutical substance but also helps control the release and absorption process in the body, making the active ingredient launch at the optimal absorption. Objectives: Survey a number of factors affecting the microcapsulation process such as the effect of solvents, the concentration of the polymer, spray drying conditions to create microcapsules. Materials and methods: the materials were diclofenac sodium microcapsules with Eudragit^® L100. Survey the effect of 3 solvents (ethanol, acetone, isopropyl alcohol), the effect of the polymer concentration (1%, 3%, 5%, 7%, 9%) compared with the active ingredients (w/w) and spray drying parameters (inlet drying air temperature 80°C, 85°C, 90°C, 95°C; pump speed input 1, 3, 5 cycles per minute; fan speed 15, 30 m³/h) to the microcapsulation process to create microcapsules with the highest spray drying efficiency and the lowest microcapsules moisture. Results: determined ethanol solvent, Eudragit L100 polymer concentration with 3% and spray drying parameters with inlet drying air temperature 85°C; pump speed input 3 cycles per minute; fan speed 15 m³/h. Conclusion: sodium diclofenac enteric-coated microcapsules by spray drying method with maximum spray drying efficiency (49.89%) and microcapsules moisture (2.72% < 4%).