NHẬN XÉT CÁC ĐẶC ĐIỂM CỦA BỆNH NHÂN CHỬA KẼ VÒI TỬ CUNG ĐIỀU TRỊ BẰNG METHOTREXATE ĐA LIỀU

Abstract

Background: Interstitial ectopic pregnancy (IEP) is a special location of ectopic pregnancy that accounts for 3%. Objectives: To analyse clinical and para clinical signs of all IEP patients have been treated by multiple methotrexate regimen and to evaluate of the results of the treatment of IEP with a multidose methotrexate regimen. Materials and methods: A prospective serial case study of women with interstitial ectopic pregnancy treated with methotrexate at the Hanoi Hospital of Obstetrics and Gynecology from January 2018 to July 2019. The treatment regimen comprised of intramuscular injection in day 1 with the dose of 1mg/kg/24 hours. The day after the test if βhCG concentration increases or decreases by <15% the above treatment would be continued on the following day. Total dose of methotrexate was 200 mg. Results: 32 eligible patients, successful treatment rate was 84.37%. The average size of gestational sac was 16.67mm; Newly formed gestational sac without cardiac activity. βhCG level was less than 10,000 UI/l (mean βhCG 4693.25 UI/l)   can   be   treated   with   multidose   intramuscular   methotrexate.   Conclusions:   Multiple intramuscular methotrexate treatment is an effective and safe treatment option for interstitial ectopic pregnancy in early stage.