EFFECTS OF PROBIOTIC SUPPLEMENT IN NON-DIALYSIS PATIENTS WITH CHRONIC KIDNEY DISEASE
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Abstract
Background: Dysbiosis of the gut microbiota may accelerate the progression of chronic kidney disease (CKD) due to increased levels of serum urea toxins. Objectives: To evaluate the effect of probiotic supplementation on the progression of chronic kidney disease and the effect of probiotics on some nutritional factors in non-dialysis patients with CKD. Materials and method: a randomized clinical intervention study on 61 CKD patients (31 patients in the probiotic group, 30 in the control group) at Can Tho General Hospital from December 2020 to December 2021. Results: women were 54.1%, the mean age was 61,9±12,9; stage 4, 5 CKD were 92%. Serum urea levels in the probiotics group decreased from 17.6±7.1 mmol/L to 14.2±6.0 mmol/L after 3 months, p=0.001. The change of serum creatinine and eGFR after treatment in both groups was not statistically significant after 1 and 3 months. After 3 months, the mean serum protein levels increased from 63.4±8.2 g/L to 69.0±7.4 g/L, p=0.001; serum albumin increased from 31.2±5.5 g/L to 34.1±4.1 g/L, p=0.001. Conclusions:Probiotics supplementation may reduce serum urea levels, improve serum protein and albumin levels, but have no effect on serum creatinine levels, eGFR, and Hb in non-dialysis patients with chronic kidney disease.
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Keywords
chronic kidney disease, probiotics, nutrition
References
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