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Date Published: 12/06/2022
Online Published: 12/06/2023
Abstract Views: 339
Views PDF: 235
Issue
No. 46 (2022)
Section
Article
How to Cite
Cao, T. C. N., & La, B. N. (2023). SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF BENZIMIDAZOLE DERIVATIVES. Cantho Journal of Medicine and Pharmacy, 46, 55-62. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/907

SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF BENZIMIDAZOLE DERIVATIVES

Thi Cam Nhung Cao1,, Bao Ngoc La1
1 Hue University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Presently, many scientists are interested in synthesis and screening of biological activity towards anti-cancer effects of new compounds. In order to create a basis for the development of new highly active cancer drugs, we selected the synthesis of new derivatives from the benzimidazole framework and tested their cytotoxic activity. Objectives: The main objective was to synthesize some benzimidazole derivatives and test their cytotoxicity on human cancer cell lines. Material and Methods: A series of benzimidazole derivatives were synthesized by the condensation of ethyl 1H-benzimidazole-2-carboxylate or 2- hydrazinobenzimidazole with substituted aromatic aldehydes. Their structural identification was based on 2D-NMR and MS data. The in vitro cytotoxic activities of all synthesized compounds against human lung carcinoma cells (A549), human breast carcinoma cells (MCF7) and human cervical carcinoma cells (Hela) were evaluated by the SRB assay. Results: Four compounds of benzimidazole were synthesized and determined their structures including: 4-methoxybenzylidene-1H-benzimidazole-2-carbohydrazide (2a),     4-chlorobenzylidene-1H-benzimidazole-2-carbohydrazide    (2b),     2-(2-(4- chlorobenzylidene)hydrazinyl)-1H-benzimidazole  (2c),     2-(2-(4-nitrobenzylidene)hydrazinyl)-1H- benzimidazole (2d). The result showed that compounds 2b and 2d exhibited activity against the tested cell lines with IC50 values ranging from 63,42 to 90,28 µg/mL. Conclusion: In this study, benzimidazole derivatives were synthesized and evaluated for their cytotoxic activity.

Article Details

Keywords

benzimidazole derivatives, synthesis, cytotoxic activity

References

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