THE SITUATION, CHARACTERISTICS OF PHENOTYPES ON PATIENTS OF STABLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
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Abstract
Background: The chronic obstructive pulmonary disease has the diversity of genetic characteristics, clinical and subclinical manifestation as well as its different prognosis in response to treatment. Objectives: Identify prevalence and clinical, subclinical characters of some phenotypes on patients of stable chronic obstructive pulmonary disease in the Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A cross-sectional study including 57 patients with stable chronic obstructive pulmonary disease and 30 patients ≥40 years old suffering from asthma and chronic bronchitis. Results: The phenotypes A and B were mainly present in our study with the percentage of 50.9% and 26.9% respectively. Chronic obstructive pulmonary disease group II and III were mainly seen with the percentage of 51.9% and 25.9% respectively. Female were 5.3%, the average age 63.89±1.04. In our study, the smoking patients ≥20 pack-year were 84%, 52.6% of patients with mMRC=1. The study also found 22.8% among them hospitalized due to acute exacerbation. The percentage of patients with eosinophils ≥ 300 cell/µl was 32.1. The combined restrictive obstructive lung disorder was about 70%. The FEV1 post bronchodilator was 63±20.3% and FEV1/FVC post bronchodilator 0.56±0.11 in average. Conclusion: The diversity of COPD phenotypes is being widely concerned, early diagnosis and phenotypic treatment to help achieve high efficiency in treatment and improve the quality of life for patients is an urgent requirement today.
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Keywords
chronic obstructive pulmonary disease, phenotype, eosinophil
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