KHẢO SÁT NỒNG ĐỘ HBA1C Ở BỆNH NHÂN THIẾU MÁU KHÔNG ĐÁI THÁO ĐƯỜNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ NĂM 2020-2021

Abstract

 Background: Haemoglobin A1C (HbA1C) is a glycated form of haemoglobin that reflects average plasma glucose level over the previous 8 to 12 weeks. However, HbA1C can be affected by multiple non-glycaemic parameters including anaemia. Objectives: 1) To describe the level of HbA1C in non-diabetic patients with iron deficiency anaemia and with hypoproliferative anaemia. 2) To investigate some factors correlated to HbA1C level in nondiabetic patients with iron deficiency anaemia. Materials and methods: A cross–sectional study on patients selected from Can Tho Central General Hospital from October 2020 to April 2021, were divided into three groups: iron deficiency anaemia (n=30), hypoproliferative anaemia (aplastic anaemia and acute leukemia) (n=30) and healthy controls (n=30). Results: The mean HbA1C level in iron deficient anaemic nondiabetic patients was significantly higher than that in the control group (5,97±0,63% compared with 5,35±0,59%, p < 0,001). The mean HbA1C level in hypoproliferative anaemic non-diabetic patients has the same pattern (5,91±0,83% compared with 5,35±0,59%, p < 0,05). There was a significant negative correlation between increased serum ferritin and HbA1C level (C    oefficient of correlation = -0,461, p < 0,05). Conclusion: HbA1C levels in iron deficient anaemic and hypoproliferative anaemic patients were significant higher than controls. Therefore, caution should be required when using HbA1C level to make diagnosis of diabetes among patients with iron-deficiency anaemia and hypoproliferative anaemia. In these situations, the use of other diagnosis criteria for diabetes (according to American Diabetes Association) is recommended.