THE PREVALENCE AND TREATMENT RESULTS OF HELICOBACTER PYLORI INFECTION IN PEPTIC ULCER OUTPATIENTS AT SOC TRANG GENERAL HOSPITAL

Phước Trường Hứa1,, Thi Tam Pham 2
1 Soc Trang General Hospital
2 Can Tho University of Medicine and Pharmacy

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Abstract

Background: Helicobacter Pylori (H.pylori) infection is one of the most common chronic bacterial infections in humans with peptic ulcer. Previous study showed that the rate of H.pylori positive through endoscopy to Test Urease quickly (Clotest) was 24.6%. Recent studies showed that the classic 3-drug regimen (OAC) was low effective. The alternative treatment of 4-drug regimens without bismuth was recommended. However, there are no studies evaluating the treatment results of this regimen. Objectives: Determine the rate of H.pylori infection in patients who were tested for Clotest through gastroduodenal endoscopy and assess the results of eradication treatment with a 4drug regimen without Bismuth. Materials and methods: Prospective descriptive study with 380 peptic ulcer patients treated as outpatients at Soc Trang General Hospital from June 2020 to May 2021. Results: Looking at a total of 380 patients participating in the study, we noted: The prevalence of H.pylori infection through endoscopy using Clotest test was 22.4%; The rate of successful eradication treatment is 88.24%. Conclusion: The prevalence of H.pylori infection through endoscopy in outpatients is relatively high, consistent with the epidemiological reports and the successful rate of treatment with a 4-drug regimen without bismuth that is still effective in Soc Trang.   

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References

1. Quách Trọng Đức, Trần Kiều Miên (2012), Điều trị loét dạ dày-tá tràng, Điều trị học nội khoa, tr.209-224.
2. Đặng Ngọc Quý Huệ (2018), “Nghiên cứu tỷ lệ kháng Clarithromycin, Levofloxacin của
Helicobacter Pylori bằng Epsilometer và hiệu quả của phác đồ EBMT ở bệnh nhân viêm dạ dày mạn”, Luận án Tiến sỹ Y học, Trường Đại học Y Dược Huế, Huế.
3. Phan Tấn Tài, Huỳnh Chí Hùng (2013), “Tỷ lệ nhiễm helicobacter pylori trên bệnh nhân nội soi dạ dày tá tràng tại bệnh viện đa khoa Phú Tân, An Giang”, Kỷ yếu nghiên cứu Khoa học Bệnh viện Đa khoa Trung tâm An Giang năm 2013, tập 1, tr.93-96.
4. Trần Thị Khánh Tường, Vũ Quốc Bảo (2017), “Hiệu quả điều trị của phác đồ 4 thuốc có bismuth trong điều trị nhiễm Helicobacter pylori”, Tạp Chí Y Dược học, Tập 7 (03).
5. Atkinson N. S. and B. Braden (2016), “Helicobacter pylori infection: Diagnostic strategies in primary diagnosis and after therapy”, Dig Dis Sci, 61(1), pp.19-24.
6. Chey W. D., G. I. Leontiadis, C. W. Howden, et al. (2017), “ACG clinical guideline: Treatment of helicobacter pylori infection”, Am J Gastroenterol, 112 (2), pp.212-239.
7. Eusebi L. H., R. M. Zagari and F. Bazzoli (2014), “Epidemiology of helicobacter pylori infection”, Helicobacter, 19 Suppl 1, pp.1-5.
8. Hao Yu, Yingjia Mao, Lijie Cong, et al. (2018), “Prevalence and genotyping of
Helicobacter pylori in endoscopic biopsy samples from a Chinese population”, Journal of Laboratory Medicine, 20180022.
9. Wang C., Liu J., Shi X., et al. (2021), “Prevalence of Helicobacter pylori Infection in Military Personnel from Northeast China: A Cross-Sectional Study”, Int J Gen Med, 14, 1499-1505.