SỬ DỤNG THUỐC CHỐNG ĐÔNG VÀ CHỐNG NGƯNG TẬP TIỂU CẦU TRÊN BỆNH NHÂN NHỒI MÁU NÃO NĂM 2020

Abstract

  Background: Cerebral infarction is always the burning issue of medicine because it is common, worldwide, of a high mortality rate, which leaves a lot of severe sequels. Objectives: (1) To determine the ratio used of the antiplatelet drugs and anticoagulants in treatment of cerebral infarction. (2) To determine the ratio and level of drug interactions of antiplatelet drugs and anticoagulants. Materials and methods: A cross-sectional observational study was conducted by reviewing 304 medical records of hospitalized patients was diagnosed with cerebral infarction in internal cardiovascular department of Vinh Long General Hospital, Vietnam during 12 months from January 2020 to January 2021. Results: In 304 patients using antiplatelet drugs and/or anticoagulants, aspirin accounted for 90.8% and clopidogrel 14.5%; enoxaparin made up 3% and acenocoumarol 5.9%. For the antithrombotic therapy, monotherapy regimen was employed most frequently 87.5%. Double and triple therapy regimens were 10% and 1.6%, respectively; of 6 different antithrombotic regimens used and the most common regimens were 1 antiplatelet drug and/or anticoagulants. The rate of drug interactions is 75%. Of all drug-drug interactions, 12.3% was classified as major and 66.7% as moderate. Conclusion: antiplatelet drugs and/or anticoagulants with value in reducing the risk of cerebral infarction and can help us to reduce mortality rate, disability and relapse.