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Date Published: 31/08/2023
Online Published: 31/07/2023
Abstract Views: 312
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DOI: https://doi.org/10.58490/ctump.2023i62.719
Issue
No. 62 (2023)
Section
Article
How to Cite
Tran, Q. K., Bui, Q. N., Ong, H. T., Nguyen, T. N. H., Nguyen, D. T., Pham, M. Q., Nguyen, B. T. H., La, G. T. V., Nguyen, H. T. H., & Nguyen, M. C. (2023). RESEARCH ON CHANGES OF CEREBROSPINAL FLUID IN NEONATES WITH SEVERE INFECTIONS. Cantho Journal of Medicine and Pharmacy, 62, 98-106. https://doi.org/10.58490/ctump.2023i62.719

RESEARCH ON CHANGES OF CEREBROSPINAL FLUID IN NEONATES WITH SEVERE INFECTIONS

Quang Khai Tran1,, Quang Nghia Bui2, Huy Thanh Ong3, Thi Ngoc Ha Nguyen4, Duc Tri Nguyen3, Minh Quan Pham2, Bui Thai Huy Nguyen2, Gia Thuy Vy La2, Hoang Tuan Hung Nguyen2, Manh Cuong Nguyen5
1 Can Tho University of medicine and pharmacy
2 Can Tho University of Medicine and Pharmacy
3 Can Tho Children’s Hospital
4 Can Tho Obstetrics and Gynecology Hospital
5 103 Military Hospital, Military Medical Academy

Main Article Content

Abstract

Background: Neonates with severe infections are the subject of concern. Bacterial meningitis is one of the most serious infectious diseases of the central nervous system in neonates. Lumbar puncture and analysis of cerebrospinal fluid (CSF) play an important role in the diagnosis.


Objectives: To describe some clinical and paraclinical characteristics of neonates with severe infections; to determine the change of CSF componentsin infants with severe infections and describe the relationship of CSF characteristics with clinical and subclinical features. Materials and method: A cross-sectional description study was conducted on 60 infants with severe infections at the Neonatal Department of Can Tho Children's Hospital from March 2021 to March 2023. Results: Most children had late-onset (58.3%). The most common clinical manifestations were fever (61.7%), lethargy (45%), jaundice (43.3%), and tachypnea (38.3%). Most of the leukocytes were at normal level (accounting for 66.7%), increased CRP accounted for 62.2%. The most changes in CSF components belonged to increased protein (61.7%) and increased cell (56.7%); decreased glucose was uncommon (6.7%). The ratio of CSF to serum glucose was affected by lethargy (p=0.020) and CRP value (p=0.016). Conclusion:  More than half of newborns with severe infections have changes in the composition of CSF, mainly in cells and proteins. Therefore, it is necessary to perform lumbar puncture in neonates with severe infectious disease and analyze CSF changes for timely diagnosis and treatment of meningitis.

Article Details

Keywords

cerebrospinal fluid, bacterial meningitis, neonate

References

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